Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | GRM8 | O00222 | 1/20 | 0.49 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11411503 | 0.89 | KMT2A (0.73) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL2535702 | 0.81 | GRM4 (0.76) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL11138902 | 0.81 | KMT2A (0.69) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL8413439 | 0.80 | PPARD (0.58) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL14227559 | 0.80 | KMT2A (0.65) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL14227557 | 0.79 | STK39 (0.67) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL9628562 | 0.78 | KMT2A (0.66) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL11306168 | 0.77 | LMNA (0.57) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL14227560 | 0.77 | KMT2A (0.59) | KMT2ALMNAMEN1POLBSMN1; SMN2 | |
| SCHEMBL10931328 | 0.77 | KMT2A (0.66) | KMT2ALMNAMEN1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11285165-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2022-03-29 | — | — | US | claimed |
| US-20210000843-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2021-01-07 | — | — | US | claimed |
| US-10646502-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY (US) | 2020-05-12 | — | — | US | claimed |
| US-20190262364-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2019-08-29 | — | — | US | claimed |
| US-10292992-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2019-05-21 | — | — | US | claimed |
| US-9884070-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2018-02-06 | — | — | US | claimed |
| US-20180008621-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2018-01-11 | — | — | US | claimed |
| US-20180008622-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2018-01-11 | — | — | US | claimed |
| EP-2268654-B1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | UNIV CALIFORNIA (US) | 2017-01-25 | — | — | EP | claimed |
| US-20110144065-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | U.S. DEPARTMENT OF ENERGY | 2011-06-16 | — | — | US | claimed |
| EP-2268654-A2 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | The Regents of the University of California (US) | 2011-01-05 | — | — | EP | claimed |
| WO-2009132020-A2 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-29 | — | — | WO | claimed |
| US-11285165-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2022-03-29 | — | — | US | disclosed |
| US-20210000843-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2021-01-07 | — | — | US | disclosed |
| US-10874678-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2020-12-29 | — | — | US | disclosed |
| US-10646502-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY (US) | 2020-05-12 | — | — | US | disclosed |
| US-9884070-B2 | Selective high-affinity polydentate ligands and methods of making such | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2018-02-06 | — | — | US | disclosed |
| US-20180008621-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2018-01-11 | — | — | US | disclosed |
| US-20180008622-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | LAWRENCE LIVERMORE NATIONAL SECURITY, LLC (US) | 2018-01-11 | — | — | US | disclosed |
| EP-2268654-B1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | UNIV CALIFORNIA (US) | 2017-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10646502-B2 | Selective high-affinity polydentate ligands and methods of making such | CD44, FCGR3B, FCGR2A | KMT2A 3857/4885LMNA 3558/4885MEN1 1828/4885 |
| US-11285165-B2 | Selective high-affinity polydentate ligands and methods of making such | CD44, FCGR3B, FCGR2A | KMT2A 3857/4885LMNA 3558/4885MEN1 1828/4885 |
| US-20110144065-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | CD44, FCGR3B, FCGR2A | KMT2A 3857/4885LMNA 3558/4885MEN1 1828/4885 |
| US-20180008621-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | CD44, FCGR3B, FCGR2A | KMT2A 3857/4885LMNA 3558/4885MEN1 1828/4885 |
| US-20180008622-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | CD44, FCGR3B, FCGR2A | KMT2A 3857/4885LMNA 3558/4885MEN1 1828/4885 |
| US-20190262364-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | CD44, FCGR3B, FCGR2A | KMT2A 3857/4885LMNA 3558/4885MEN1 1828/4885 |
| US-10874678-B2 | Selective high-affinity polydentate ligands and methods of making such | CD44, FCGR3B, FCGR2A | KMT2A 3857/4885LMNA 3558/4885MEN1 1828/4885 |
| US-20210000843-A1 | SELECTIVE HIGH-AFFINITY POLYDENTATE LIGANDS AND METHODS OF MAKING SUCH | CD44, FCGR3B, FCGR2A | KMT2A 3857/4885LMNA 3558/4885MEN1 1828/4885 |
| US-10292992-B2 | Selective high-affinity polydentate ligands and methods of making such | CD44, FCGR3B, FCGR2A | KMT2A 3857/4885LMNA 3558/4885MEN1 1828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.