SCHEMBL9628562

SCHEMBL9628562

O=C(NC(=O)c1ccccc1Cl)Nc1ccc(Oc2ccc(C(F)(F)F)cn2)c(Cl)c1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.66
POLB P06746 2/20 0.66
MEN1 O00255 1/20 0.66
LMNA P02545 1/20 0.66
SMN1; SMN2 Q16637 1/20 0.66
GCGR P47871 1/20 0.60
GRM8 O00222 1/20 0.52
GRM7 Q14831 1/20 0.52
GRM4 Q14833 1/20 0.52
TDP1 Q9NUW8 1/20 0.51
BRAF P15056 1/20 0.49
KDR P35968 1/20 0.49
MAPK14 Q16539 1/20 0.49
TNNI3K Q59H18 1/20 0.49
PNLIP P16233 1/20 0.48
RPS6KA3 P51812 1/20 0.48
PYGL P06737 1/20 0.46
PLCG2 P16885 1/20 0.46
NPC1 O15118 1/20 0.45
PKM P14618 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11022243 0.91 GCGR (0.56) KMT2APOLBMEN1LMNASMN1; SMN2
SCHEMBL10495588 0.89 KMT2A (0.56) KMT2APOLBMEN1LMNASMN1; SMN2
SCHEMBL11575043 0.89 PYGL (0.52) KMT2APOLBMEN1LMNASMN1; SMN2
SCHEMBL10353936 0.85 GCGR (0.63) KMT2APOLBMEN1LMNASMN1; SMN2
SCHEMBL14227559 0.85 KMT2A (0.65) KMT2APOLBMEN1LMNASMN1; SMN2
SCHEMBL10931328 0.83 KMT2A (0.66) KMT2APOLBMEN1LMNASMN1; SMN2
SCHEMBL8659667 0.83 GCGR (0.60) KMT2APOLBMEN1LMNASMN1; SMN2
SCHEMBL2535702 0.82 GRM4 (0.76) KMT2APOLBMEN1LMNASMN1; SMN2
SCHEMBL11248757 0.82 GCGR (0.59) KMT2APOLBMEN1LMNASMN1; SMN2
SCHEMBL10823692 0.82 KMT2A (0.55) KMT2APOLBMEN1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5098907-A Nonionic surfactants ISHIHARA SANGYO KAISHA LTD. (JP) 1992-03-24 US claimed
US-5036072-A Benzoyl urea derivative ISHIHARA SANGYO KAISHA LTD. (JP) 1991-07-30 US claimed
EP-0380048-A2 Use of benzoyl urea derivatives as antiviral agents ISHIHARA SANGYO KAISHA LTD. (JP) 1990-08-01 EP claimed
JP-62000062-A None JP disclosed
JP-S6262-A PRODUCTION OF BENZOYLUREA COMPOUND ISHIHARA SANGYO KAISHA LTD 1987-01-06 JP disclosed