Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PRLHR | P49683 | 1/20 | 0.35 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL867560 | 0.86 | CHRNA7 (0.44) | CHRNA7MGLLSCN9ASCN10AJAK2 | |
| SCHEMBL120247 | 0.80 | CHRNA7 (0.47) | CHRNA7MGLLJAK2JAK1HRH4 | |
| SCHEMBL868379 | 0.76 | MGLL (0.49) | CHRNA7MGLLSCN9AJAK2JAK1 | |
| SCHEMBL2130918 | 0.75 | CHRNA7 (0.45) | CHRNA7MGLLTEAD1 | |
| SCHEMBL2720564 | 0.75 | CHRNA7 (0.45) | CHRNA7MGLLTEAD1 | |
| SCHEMBL694263 | 0.74 | SCN9A (0.49) | CHRNA7MGLLSCN9ASCN10AJAK2 | |
| SCHEMBL698796 | 0.74 | MGLL (0.47) | CHRNA7MGLLSCN9ASCN10AJAK2 | |
| SCHEMBL2135364 | 0.72 | RBP4 (0.45) | CHRNA7MGLLSCN9AJAK2JAK1 | |
| SCHEMBL16564221 | 0.72 | MGLL (0.53) | CHRNA7MGLLSCN9ASCN10AJAK2 | |
| SCHEMBL16564435 | 0.72 | MGLL (0.53) | CHRNA7MGLLJAK2JAK1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637498-B2 | Oxopiperazine-azetidine amides and oxodiazepine-azetidine amides as monoacylglycerol lipase inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2014-01-28 | — | — | US | disclosed |
| US-20120077797-A1 | OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077797-A1 | OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | LPL, PNLIP, LIPA | CHRNA7 1801/4885MGLL 6/4885SCN9A 158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.