Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 6/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 11/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2056257 | 0.91 | ADRB2 (0.56) | ADRB3ADRB2ADRB1HSD17B10KDM4E | |
| SCHEMBL10115622 | 0.84 | ADRB2 (0.62) | ADRB3ADRB2ADRB1HSD17B10KDM4E | |
| SCHEMBL2054514 | 0.83 | ADRB2 (0.50) | ADRB3ADRB2ADRB1HSD17B10KDM4E | |
| SCHEMBL7152175 | 0.81 | ADRB2 (0.61) | ADRB3ADRB2ADRB1HSD17B10CYP1A2 | |
| SCHEMBL7152166 | 0.81 | ADRB2 (0.61) | ADRB3ADRB2ADRB1HSD17B10CYP1A2 | |
| SCHEMBL20420611 | 0.81 | ADRB2 (0.64) | ADRB3ADRB2ADRB1HSD17B10CYP1A2 | |
| SCHEMBL13906446 | 0.81 | ADRB2 (0.61) | ADRB3ADRB2ADRB1HSD17B10CYP1A2 | |
| SCHEMBL3824204 | 0.81 | ADRB2 (0.64) | ADRB3ADRB2ADRB1HSD17B10CYP1A2 | |
| SCHEMBL13897129 | 0.80 | CYP3A4 (0.59) | ADRB3ADRB2ADRB1HSD17B10CYP1A2 | |
| SCHEMBL10391023 | 0.79 | KDM4E (0.62) | ADRB3ADRB2ADRB1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288391-B2 | Epithelial Sodium Channel and Acid Sensitive Ion Channel modulators; blocking or enhancing salt and sour tastes; additives in chocolate, ice cream, beverages, candies, or pet foods; side effect reduction | PARION SCIENCES, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-8124607-B2 | Poly aromatic pyrazinoylguanidine sodium channel blockers | PARION SCIENCES, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-20090214444-A1 | POLY AROMATIC SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| US-20080293740-A1 | METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS | PARION SCIENCES, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080249109-A1 | PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS | PARION SCIENCES, INC. (US) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249109-A1 | PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS | TAS2R5, TAS2R9, TAS2R19 | ADRB3 1162/4885ADRB2 699/4885ADRB1 760/4885 |
| US-20080293740-A1 | METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS | ASIC1, ASIC3, TRPV1 | ADRB3 1255/4885ADRB2 1149/4885ADRB1 993/4885 |
| US-20090214444-A1 | POLY AROMATIC SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCNN1B | ADRB3 107/4885ADRB2 104/4885ADRB1 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.