Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 19/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10115642 | 0.93 | SCNN1A (0.51) | SCNN1AKDM4ECYP1A2MEN1CYP2C19 | |
| SCHEMBL15452063 | 0.93 | SCNN1A (0.51) | SCNN1AKDM4ECYP1A2NPC1ALDH1A1 | |
| SCHEMBL13620861 | 0.91 | SCNN1A (0.48) | SCNN1AKDM4ECYP1A2MEN1CYP2C19 | |
| SCHEMBL9913781 | 0.90 | SCNN1A (0.71) | SCNN1A | |
| SCHEMBL709519 | 0.87 | SCNN1A (0.49) | SCNN1AKDM4ECYP1A2NPC1ALDH1A1 | |
| SCHEMBL708473 | 0.87 | SCNN1A (0.51) | SCNN1AKDM4ECYP1A2NPC1ALDH1A1 | |
| SCHEMBL10116013 | 0.86 | SCNN1A (0.48) | SCNN1AKDM4ECYP1A2NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL709294 | 0.86 | SCNN1A (0.48) | SCNN1AKDM4ECYP1A2NPC1ALDH1A1 | |
| SCHEMBL16808345 | 0.86 | SCNN1A (0.45) | SCNN1AKDM4ECYP1A2NPC1ALDH1A1 | |
| SCHEMBL707207 | 0.84 | SCNN1A (0.46) | SCNN1AKDM4ECYP1A2ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140031371-A1 | POLY AROMATIC SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2014-01-30 | — | — | US | disclosed |
| US-8575176-B2 | Heteroaromatic pyrazinoylguanidine sodium channel blockers | PARION SCIENCES, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8288391-B2 | Epithelial Sodium Channel and Acid Sensitive Ion Channel modulators; blocking or enhancing salt and sour tastes; additives in chocolate, ice cream, beverages, candies, or pet foods; side effect reduction | PARION SCIENCES, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-8288391-B2 | Epithelial Sodium Channel and Acid Sensitive Ion Channel modulators; blocking or enhancing salt and sour tastes; additives in chocolate, ice cream, beverages, candies, or pet foods; side effect reduction | PARION SCIENCES, INC. (US) | 2012-10-16 | — | — | US | disclosed |
| US-20120116083-A1 | HETEROAROMATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2012-05-10 | — | — | US | disclosed |
| US-8124607-B2 | Poly aromatic pyrazinoylguanidine sodium channel blockers | PARION SCIENCES, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-8124607-B2 | Poly aromatic pyrazinoylguanidine sodium channel blockers | PARION SCIENCES, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| WO-2009139948-A1 | POLY AROMATIC SODIUM CHANNEL BLOCKERS | JOHNSON MICHAEL R (US) | 2009-11-19 | — | — | WO | disclosed |
| US-20090214444-A1 | POLY AROMATIC SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| US-20090214444-A1 | POLY AROMATIC SODIUM CHANNEL BLOCKERS | PARION SCIENCES, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| US-20080293740-A1 | METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS | PARION SCIENCES, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293740-A1 | METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS | PARION SCIENCES, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008124491-A1 | PYRAZINOYLGUANIDINE COMPOUNDS FOR USE TASTE MODULATORS | PARION SCIENCES, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008124496-A1 | METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH, AND CENTRAL NERVOUS SYSTEM DISORDERS | PARION SCIENCES, INC. (US) | 2008-10-16 | — | — | WO | disclosed |
| US-20080249109-A1 | PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS | PARION SCIENCES, INC. (US) | 2008-10-09 | — | — | US | disclosed |
| US-20080249109-A1 | PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS | PARION SCIENCES, INC. (US) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249109-A1 | PYRAZINOYLGUANIDINE COMPOUNDS FOR USE AS TASTE MODULATORS | TAS2R5, TAS2R9, TAS2R19 | SCNN1A 65/4885KDM4E 2672/4885CYP1A2 3481/4885 |
| US-20080293740-A1 | METHOD OF TREATING ACID-SENSING ION CHANNEL MEDIATED PAIN, COUGH SUPPRESSION, AND CENTRAL NERVOUS SYSTEM DISORDERS | ASIC1, ASIC3, TRPV1 | SCNN1A 75/4885KDM4E 4543/4885CYP1A2 2546/4885 |
| US-20120116083-A1 | HETEROAROMATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, KCNH1 | SCNN1A 16/4885KDM4E 3151/4885CYP1A2 416/4885 |
| US-20090214444-A1 | POLY AROMATIC SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCNN1B | SCNN1A 11/4885KDM4E 2068/4885CYP1A2 745/4885 |
| US-20140031371-A1 | POLY AROMATIC SODIUM CHANNEL BLOCKERS | HCN4, SCN2B, SCNN1B | SCNN1A 11/4885KDM4E 2068/4885CYP1A2 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.