Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.43 |
| ▸ | HTR1A | P08908 | 6/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1011388 | 0.99 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3HTR1AAKR1B1 | |
| SCHEMBL1009494 | 0.88 | AKR1B1 (0.51) | AKR1B1MAPTMEN1KMT2ALMNA | |
| SCHEMBL1013799 | 0.86 | LTA4H (0.42) | AKR1B1MEN1KMT2AALOX5ADAMTS5 | |
| Hydrochloric Acid SCHEMBL1010352 | 0.84 | ADAMTS5 (0.55) | ADAMTS5 | |
| SCHEMBL1011559 | 0.83 | ADAMTS5 (0.43) | AKR1B1ADAMTS5MMP3MMP13 | |
| SCHEMBL27233690 | 0.82 | FAAH (0.46) | CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27233592 | 0.79 | RAB9A (0.43) | AKR1B1MAPTALDH1A1LMNAALOX5 | |
| SCHEMBL28683291 | 0.79 | IKBKB (0.54) | CYP1A2CYP3A4CYP2D6MAPK1BLM | |
| SCHEMBL27763712 | 0.78 | ELANE (0.50) | AKR1B1MEN1ALDH1A1KMT2ALMNA | |
| SCHEMBL27233568 | 0.78 | HTR2C (0.50) | AKR1B1MAPTMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076508-B1 | BIARYL ETHER UREA COMPOUNDS | PFIZER PROD INC (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-2076508-A2 | BIARYL ETHER UREA COMPOUNDS | Pfizer Products Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008047229-A2 | BIARYL ETHER UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-04-24 | — | — | WO | disclosed |