Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25418921 | 0.90 | HTR6 (0.70) | HTR6HTR2AMTNR1AMTNR1BNQO2 | |
| SCHEMBL8271864 | 0.88 | HTR6 (0.62) | HTR6MTNR1AMTNR1BNQO2HDAC3 | |
| SCHEMBL8270015 | 0.84 | ADRB2 (0.59) | HTR6HTR2ADYRK1AADRB2CNR2 | |
| SCHEMBL9883700 | 0.79 | HTR6 (0.45) | HTR6HTR2AMTNR1AMTNR1BNQO2 | |
| SCHEMBL19650681 | 0.78 | HTR6 (0.52) | HTR6CNR2NR1D1 | |
| SCHEMBL8271739 | 0.76 | ALDH1A1 (0.52) | HTR6CNR2SSTR5MEN1KMT2A | |
| SCHEMBL24878072 | 0.75 | HTR6 (0.57) | HTR6HTR2AMTNR1AMTNR1BNQO2 | |
| SCHEMBL984866 | 0.72 | L3MBTL1 (0.47) | HTR6DYRK1ACNR2MEN1KMT2A | |
| SCHEMBL25623396 | 0.71 | HTR6 (0.81) | HTR6HTR2A | |
| SCHEMBL12641863 | 0.70 | HTR6 (0.51) | HTR6SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781639-B1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2012-01-25 | — | — | EP | disclosed |