Sugi Predict

Sugi Predict / Compounds / SCHEMBL10120481

SCHEMBL10120481

SCHEMBL10120481

Cc1ccc(F)c(C)c1C#N

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 3/20 0.37
▸ CYP2C19 P33261 2/20 0.37
▸ TRPV4 Q9HBA0 1/20 0.37
▸ USP8 P40818 1/20 0.37
▸ USP7 Q93009 1/20 0.37
▸ GAA P10253 1/20 0.36
▸ GFER P55789 1/20 0.36
▸ KDM4E B2RXH2 5/20 0.35
▸ ALDH1A1 P00352 4/20 0.35
▸ HSD17B10 Q99714 2/20 0.35
▸ HPGD P15428 2/20 0.35
▸ MAPT P10636 1/20 0.35
▸ ALOX15 P16050 1/20 0.35
▸ APOBEC3G Q9HC16 1/20 0.35
▸ LMNA P02545 2/20 0.35
▸ KMT2A Q03164 3/20 0.34
▸ POLB P06746 1/20 0.34
▸ MEN1 O00255 2/20 0.33
▸ TSHR P16473 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8090040 0.86 TRPV4 (0.39) CYP1A2TRPV4USP8USP7GAA
SCHEMBL13082493 0.82 CYP1A2 (0.37) CYP1A2CYP2C19TRPV4GAAGFER
SCHEMBL17192918 0.82 TRPV4 (0.37) CYP1A2CYP2C19TRPV4USP8USP7
SCHEMBL19914848 0.80 CYP1A2 (0.42) CYP1A2CYP2C19GAAKDM4EALDH1A1
SCHEMBL8112763 0.78 ALDH1A1 (0.36) CYP1A2CYP2C19TRPV4GAAGFER
SCHEMBL27215201 0.78 USP8 (0.35) CYP1A2TRPV4USP8USP7GAA
SCHEMBL12099338 0.78 GAA (0.37) CYP1A2CYP2C19TRPV4USP8USP7
SCHEMBL16136624 0.77 TRPV4 (0.37) CYP1A2CYP2C19TRPV4GAAGFER
SCHEMBL7975208 0.77 CYP1A2 (0.46) CYP1A2CYP2C19GAAKDM4EALDH1A1
SCHEMBL31050110 0.77 CYP1A2 (0.46) CYP1A2CYP2C19GAAKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151638-A2 COMPOUNDS FOR FGFRS INHIBITORS COGENT BIOSCIENCES, INC. (US) 2024-07-18 — — WO disclosed
US-8835423-B2 Azepine inhibitors of janus kinases INCYTE CORPORATION (US) 2014-09-16 — — US disclosed
US-20140031344-A1 AZEPINE INHIBITORS OF JANUS KINASES INCYTE CORPORATION (US) 2014-01-30 — — US disclosed
US-8563541-B2 Azepine inhibitors of Janus kinases INCYTE CORPORATION (US) 2013-10-22 — — US disclosed
US-20120040975-A1 BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF MERCK SHARP & DOHME CORP. 2012-02-16 — — US disclosed
US-20090197869-A1 AZEPINE INHIBITORS OF JANUS KINASES INCYTE CORPORATION, A DELAWARE CORPORATION 2009-08-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120040975-A1 BRIDGED BICYCLIC HETEROCYCLE DERIVATIVES AND METHODS OF USE THEREOF GPR119, BDKRB2, GLP1R CYP1A2 1022/4885CYP2C19 566/4885TRPV4 369/4885
US-20090197869-A1 AZEPINE INHIBITORS OF JANUS KINASES JAK1, JAK3, JAK2 CYP1A2 2692/4885CYP2C19 2144/4885TRPV4 4030/4885
US-20140031344-A1 AZEPINE INHIBITORS OF JANUS KINASES JAK1, JAK3, JAK2 CYP1A2 2692/4885CYP2C19 2144/4885TRPV4 4030/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.