Sugi Predict

Sugi Predict / Compounds / SCHEMBL10126445

SCHEMBL10126445

SCHEMBL10126445

O=C(Oc1c(F)c(F)c(F)c(F)c1F)c1ccc(O)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SENP1 Q9P0U3 1/20 0.59
▸ CA12 O43570 4/20 0.55
▸ CA1 P00915 4/20 0.55
▸ CA2 P00918 4/20 0.55
▸ CA7 P43166 4/20 0.55
▸ CA9 Q16790 4/20 0.55
▸ CA14 Q9ULX7 4/20 0.55
▸ ESR1 P03372 4/20 0.50
▸ ESR2 Q92731 2/20 0.50
▸ ALDH1A1 P00352 3/20 0.47
▸ TSHR P16473 2/20 0.47
▸ CHRM1 P11229 1/20 0.47
▸ SLC6A2 P23975 1/20 0.47
▸ KDR P35968 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ MEN1 O00255 1/20 0.46
▸ KMT2A Q03164 1/20 0.46
▸ LMNA P02545 4/20 0.44
▸ MAPK1 P28482 2/20 0.44
▸ CYP1A2 P05177 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5889497 0.92 SENP1 (0.47) SENP1CA12CA1CA2CA7
SCHEMBL26032270 0.87 SENP1 (0.54) SENP1CA12CA1CA2CA7
SCHEMBL23235066 0.86 RAB9A (0.49) SENP1CA1CA2MEN1KMT2A
SCHEMBL8712521 0.84 CA1 (0.55) CA12CA1CA2CA7CA9
SCHEMBL15712039 0.84 TDP1 (0.55) ESR1ESR2ALDH1A1TDP1KMT2A
SCHEMBL27682095 0.82 PARP10 (0.53) SENP1CA1CA2ALDH1A1TSHR
SCHEMBL28796940 0.82 KMT2A (0.49) CA1CA2ALDH1A1TSHRMEN1
SCHEMBL7086238 0.82 TSHR (0.54) ALDH1A1TSHRTDP1MEN1KMT2A
SCHEMBL30267315 0.81 CA1 (0.60) CA1CA2ESR1ESR2MEN1
SCHEMBL29996962 0.79 TSHR (0.47) ALDH1A1TSHRTDP1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1807436-B1 HETEROBIFUNCTIONAL POLY(ETHYLENE GLYCOL) AND USES THEREOF INTEZYNE TECHNOLOGIES INC (US) 2014-06-18 — — EP disclosed
WO-2013106097-A1 POLY(ETHYLENE GLYCOL) DERIVATIVES FOR CLICK CHEMISTRY INTEZYNE TECHNOLOGIES, INC. (US) 2013-07-18 — — WO disclosed
US-20130178600-A1 POLY(ETHYLENE GLYCOL) DERIVATIVES FOR CLICK CHEMISTRY INTEZYNE TECHNOLOGIES, INC. (US) 2013-07-11 — — US disclosed
US-20130178600-A1 POLY(ETHYLENE GLYCOL) DERIVATIVES FOR CLICK CHEMISTRY INTEZYNE TECHNOLOGIES, INC. (US) 2013-07-11 — — US disclosed
EP-2502941-A1 Heterobifunctional poly (ethylene glycol) and uses thereof Intezyne Technologies Inc. (US) 2012-09-26 — — EP disclosed
US-8268936-B2 Synthesis of hybrid block copolymers and uses thereof INTEZYNE TECHNOLOGIES, INC. (US) 2012-09-18 — — US disclosed
US-8268936-B2 Synthesis of hybrid block copolymers and uses thereof INTEZYNE TECHNOLOGIES, INC. (US) 2012-09-18 — — US disclosed
US-20120226050-A1 POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS INTEZYNE TECHNOLOGIES, INC. (US) 2012-09-06 — — US disclosed
US-20120226050-A1 POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS INTEZYNE TECHNOLOGIES, INC. (US) 2012-09-06 — — US disclosed
US-8212083-B2 Use in PEGylation of biologicals; variety of terminal functional groups; made by polymerizing ethylene oxide on initiators such as N-(hydroxyalkyl) imines or N,N-bis(diphenyloxophosphino)-N-hydroxyalkylamines INTEZYNE TECHNOLOGIES, INC. (US) 2012-07-03 — — US disclosed
US-7560588-B2 Poly(ethylene glycol) containing chemically disparate endgroups INTEZYNE TECHNOLOGIES, INC. (US) 2009-07-14 — — US disclosed
US-20080207913-A1 Poly(ethylene glycol) containing chemically disparate endgroups INTEZYNE TECHNOLOGIES (US) 2008-08-28 — — US disclosed
US-20080207913-A1 Poly(ethylene glycol) containing chemically disparate endgroups INTEZYNE TECHNOLOGIES (US) 2008-08-28 — — US disclosed
US-20080188638-A1 Heterobifunctional poly(ethyleneglycol) containing acid-labile amino protecting groups and uses thereof INTEZYNE TECHNOLOGIES (US) 2008-08-07 — — US disclosed
US-20080188638-A1 Heterobifunctional poly(ethyleneglycol) containing acid-labile amino protecting groups and uses thereof INTEZYNE TECHNOLOGIES (US) 2008-08-07 — — US disclosed
WO-2007127473-A2 POLY (ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS INTEZYNE TECHNOLOGIES, INC. (US) 2007-11-08 — — WO disclosed
US-4849419-A 7-oxo-4-thia-azabicyclo[3,2,0]hept-2-ene derivatives HOECHST UK LIMITED (GB) 1989-07-18 — — US disclosed
US-4795748-A Antibacterial 7-oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene derivatives HOECHST UK LIMITED (GB) 1989-01-03 — — US disclosed
EP-0174561-A1 7-Oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene derivatives HOECHST UK LIMITED (GB) 1986-03-19 — — EP disclosed
EP-0170028-A1 Antibacterial 7-oxo-4-thia-1-azabicyclo[3,2,0]hept-2-ene derivatives HOECHST UK LIMITED (GB) 1986-02-05 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080188638-A1 Heterobifunctional poly(ethyleneglycol) containing acid-labile amino protecting groups and uses thereof LNPEP, GNE, DNPEP SENP1 1523/4885CA12 701/4885CA1 793/4885
US-20120226050-A1 POLY(ETHYLENE GLYCOL) CONTAINING CHEMICALLY DISPARATE ENDGROUPS GNE, EPRS1, ALG1 SENP1 3010/4885CA12 1126/4885CA1 2195/4885
US-20080207913-A1 Poly(ethylene glycol) containing chemically disparate endgroups GNE, EPRS1, ALG1 SENP1 3010/4885CA12 1126/4885CA1 2195/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.