Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PNMT | P11086 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL994308 | 0.84 | HTT (0.80) | HTTL3MBTL1ALDH1A1LMNAGAA | |
| SCHEMBL1046567 | 0.84 | HTT (0.67) | HTTL3MBTL1ALDH1A1LMNAGAA | |
| SCHEMBL1046568 | 0.84 | HTT (0.67) | HTTL3MBTL1ALDH1A1LMNAGAA | |
| SCHEMBL18186283 | 0.83 | HTT (0.66) | HTTL3MBTL1ALDH1A1LMNAGAA | |
| SCHEMBL28322852 | 0.83 | ALDH1A1 (0.70) | HTTL3MBTL1ALDH1A1LMNAGAA | |
| SCHEMBL10126813 | 0.83 | ALDH1A1 (0.49) | HTTL3MBTL1ALDH1A1LMNAGAA | |
| SCHEMBL31453591 | 0.82 | ALDH1A1 (0.50) | HTTALDH1A1LMNAGAASMN1; SMN2 | |
| SCHEMBL6052095 | 0.82 | ALDH1A1 (0.73) | HTTL3MBTL1ALDH1A1LMNAGAA | |
| SCHEMBL10036393 | 0.82 | HTT (0.64) | HTTL3MBTL1ALDH1A1LMNAGAA | |
| SCHEMBL6052093 | 0.82 | ALDH1A1 (0.73) | HTTL3MBTL1ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240010655-A1 | DIHYDROIMIDAZO PYRIMIDO PYRIMIDINONE COMPOUND | Impact Therapeutics (Shanghai), Inc (CN) | 2024-01-11 | — | — | US | disclosed |
| US-9487491-B2 | Diamino heterocyclic carboxamide compound | ASTELLAS PHARMA INC. (JP) | 2016-11-08 | — | — | US | disclosed |
| US-8969336-B2 | Diamino heterocyclic carboxamide compound | ASTELLAS PHARMA INC. (JP) | 2015-03-03 | — | — | US | disclosed |
| US-20140371196-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-12-18 | — | — | US | disclosed |
| US-20120040968-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | WATERS TECHNOLOGIES CORPORATION (US) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371196-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | EML4, ALK, ERBB4 | HTT 3739/4885L3MBTL1 1714/4885ALDH1A1 1554/4885 |
| US-20240010655-A1 | DIHYDROIMIDAZO PYRIMIDO PYRIMIDINONE COMPOUND | WEE1, WEE2, NME1 | HTT 4474/4885L3MBTL1 2766/4885ALDH1A1 1177/4885 |
| US-20120040968-A1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | EML4, ALK, ERBB4 | HTT 3739/4885L3MBTL1 1714/4885ALDH1A1 1554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.