Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10182137 | 0.84 | MTNR1A (0.50) | MAPTCTSKCTSSGAAPOLB | |
| SCHEMBL171693 | 0.81 | MAPT (0.65) | MAPTCTSKCTSSGAAPOLB | |
| SCHEMBL18683876 | 0.80 | MAPT (0.63) | MAPTCTSKCTSSPOLBLMNA | |
| SCHEMBL14562078 | 0.79 | POLB (0.69) | POLBLMNANPC1 | |
| SCHEMBL2065837 | 0.78 | MAPT (1.00) | MAPTGAAPOLBTDP1NPC1 | |
| SCHEMBL13948407 | 0.76 | MAPT (0.57) | MAPTGAAPOLBLMNATDP1 | |
| SCHEMBL20961904 | 0.76 | KMT2A (0.59) | GAAPOLBNPC1 | |
| Hydrochloric Acid SCHEMBL15329323 | 0.76 | MAPT (0.94) | MAPTGAAPOLBTDP1NPC1 | |
| SCHEMBL12311263 | 0.74 | ALDH1A1 (0.59) | MAPTGAALMNAMTNR1AMTNR1B | |
| SCHEMBL11526032 | 0.73 | MAPT (0.83) | MAPTCTSKCTSSGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2412711-A1 | INDAZOLEPROPIONIC ACID AMIDE COMPOUND | Mitsubishi Tanabe Pharma Corporation (JP) | 2012-02-01 | — | — | EP | disclosed |
| US-20120016117-A1 | INDAZOLEPROPIONIC ACID AMIDE COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-01-19 | — | — | US | disclosed |
| US-20120016117-A1 | INDAZOLEPROPIONIC ACID AMIDE COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-01-19 | — | — | US | disclosed |
| US-8022059-B2 | Indazole acrylic acid amide compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-09-20 | — | — | US | disclosed |
| US-20100256108-A1 | INDAZOLE ACRYLIC ACID AMIDE COMPOUND | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120016117-A1 | INDAZOLEPROPIONIC ACID AMIDE COMPOUND | SCN9A, SCN1A, SCN1B | MAPT 4411/4885CTSK 4330/4885CTSS 4539/4885 |
| US-20100256108-A1 | INDAZOLE ACRYLIC ACID AMIDE COMPOUND | KCNH2, KCNH3, KCNJ11 | MAPT 4800/4885CTSK 3604/4885CTSS 4607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.