Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.59 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.59 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.59 |
| ▸ | MAOB | P27338 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14864480 | 0.94 | GSTP1 (0.63) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL128703 | 0.94 | LMNA (0.67) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL1702909 | 0.90 | MAOB (0.62) | GSTP1MAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL16603392 | 0.90 | MAOB (0.62) | GSTP1MAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL18635916 | 0.90 | MAOB (0.62) | GSTP1MAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL12918621 | 0.90 | MAOB (0.62) | GSTP1MAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL197017 | 0.90 | LMNA (0.72) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL17081101 | 0.89 | LMNA (0.57) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL8736979 | 0.89 | LMNA (0.60) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL23483029 | 0.88 | LMNA (0.69) | LMNACYP1A2PTGS1SLC6A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530689-B2 | Processes for the preparation of biphenyl compounds | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-09-10 | — | — | US | disclosed |
| US-8119617-B2 | aSMase inhibitors | NOVARTIS AG (CH) | 2012-02-21 | — | — | US | disclosed |
| US-8119617-B2 | aSMase inhibitors | NOVARTIS AG (CH) | 2012-02-21 | — | — | US | disclosed |
| US-20110207957-A1 | PROCESSES FOR THE PREPARATION OF BIPHENYL COMPOUNDS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-08-25 | — | — | US | disclosed |
| US-20100022482-A1 | aSMase inhibitors | NOVARTIS AG (CH) | 2010-01-28 | — | — | US | disclosed |
| US-20100022482-A1 | aSMase inhibitors | NOVARTIS AG (CH) | 2010-01-28 | — | — | US | disclosed |
| CN-101306995-A | Binaphthalenol derivatives and uses thereof | CHITEC TECHNOLOGY CO LTD (CN) | 2008-11-19 | — | — | CN | disclosed |
| US-7416791-B1 | Osmium complexes and related organic light-emitting devices | UNIVERSITY OF WASHINGTON (US) | 2008-08-26 | — | — | US | disclosed |
| US-7416791-B1 | Osmium complexes and related organic light-emitting devices | UNIVERSITY OF WASHINGTON (US) | 2008-08-26 | — | — | US | disclosed |
| WO-2008022771-A1 | AMIDES AS SPHINGOMYELINE INHIBITORS | NOVARTIS AG (CH) | 2008-02-28 | — | — | WO | disclosed |
| CN-1729429-A | Color filter black matrix resist composition and carbon black dispersion composition for the same | SHOWA DENKO KK (JP) | 2006-02-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022482-A1 | aSMase inhibitors | SMPD1, SMPD3, SMPD2 | LMNA 1589/4885CYP1A2 281/4885PTGS1 1463/4885 |
| US-20110207957-A1 | PROCESSES FOR THE PREPARATION OF BIPHENYL COMPOUNDS | C1S, BAX, C9 | LMNA 1681/4885CYP1A2 295/4885PTGS1 3649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.