Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 3/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014714 | 0.83 | LMNA (0.38) | LMNAALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL1013043 | 0.82 | SLC22A12 (0.39) | SLC22A12ALDH1A1ELANEHPGDTSHR | |
| SCHEMBL1013013 | 0.81 | SMN1; SMN2 (0.42) | LMNAALDH1A1MAPTELANESMN1; SMN2 | |
| SCHEMBL1014656 | 0.78 | ALDH1A1 (0.36) | LMNAALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL1015466 | 0.77 | S1PR1 (0.47) | S1PR1 | |
| SCHEMBL1015308 | 0.77 | S1PR1 (0.57) | S1PR1 | |
| SCHEMBL1016210 | 0.74 | S1PR1 (0.55) | S1PR1 | |
| SCHEMBL2718240 | 0.68 | FFAR1 (0.49) | — | |
| SCHEMBL1014642 | 0.66 | HTT (0.35) | SLC22A12ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL28512976 | 0.65 | ADAMTS5 (0.35) | LMNAXDHSLC22A12ELANEMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271643-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009133136-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |