Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014714 | 0.83 | LMNA (0.38) | ALDH1A1TSHRLMNAKDM4EKMT2A | |
| SCHEMBL1014655 | 0.83 | SSTR4 (0.33) | LMNAADRB2ADRB1ADRB3KDM4E | |
| SCHEMBL1014258 | 0.82 | CYP1A2 (0.41) | LMNAHSD17B10CNR1 | |
| SCHEMBL1013044 | 0.78 | LMNA (0.36) | ALDH1A1TSHRLMNAKDM4EKMT2A | |
| SCHEMBL2716315 | 0.71 | CYP4F2 (0.40) | ALDH1A1KMT2AMEN1TDP1L3MBTL1 | |
| SCHEMBL1015274 | 0.69 | DUT (0.30) | — | |
| SCHEMBL10729119 | 0.66 | LMNA (0.54) | ALDH1A1LMNAKDM4EKMT2AMEN1 | |
| SCHEMBL10637123 | 0.65 | KDM4E (0.52) | ALDH1A1KDM4EHPGDHSD17B10CNR1 | |
| SCHEMBL11983613 | 0.64 | CYP1A2 (0.40) | LMNAKMT2ATDP1L3MBTL1CNR1 | |
| SCHEMBL145642 | 0.64 | ALDH1A1 (0.63) | ALDH1A1TSHRADRB2ADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271643-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009133136-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |