Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PTGIR | P43119 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5533968 | 0.85 | NPSR1 (0.45) | TRPM8HCAR2SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL5933542 | 0.76 | ALDH1A1 (0.48) | TRPM8CYP2C19SMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL10566831 | 0.74 | GAA (0.41) | TRPM8SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL15676626 | 0.72 | HCAR2 (0.45) | TRPM8HCAR2SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL2091758 | 0.71 | TRPM8 (0.56) | TRPM8CYP2C19SMN1; SMN2ALDH1A1PTGIR | |
| SCHEMBL15519612 | 0.71 | HCAR2 (0.34) | HCAR2 | |
| SCHEMBL16969128 | 0.68 | ACHE (0.52) | TRPM8SMN1; SMN2ALDH1A1NFE2L2KMT2A | |
| SCHEMBL2486041 | 0.68 | ALDH1A1 (0.52) | TRPM8CYP2C19SMN1; SMN2ALDH1A1KEAP1 | |
| SCHEMBL28210239 | 0.68 | HCAR2 (0.45) | TRPM8HCAR2SMN1; SMN2 | |
| SCHEMBL2490876 | 0.67 | TRPM8 (0.51) | TRPM8CYP2C19ALDH1A1PTGIRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |