Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 3/20 | 0.40 |
| ▸ | KDM4A | O75164 | 3/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 3/20 | 0.40 |
| ▸ | KDM3B | Q7LBC6 | 3/20 | 0.40 |
| ▸ | HIF1AN | Q9NWT6 | 3/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012139 | 0.84 | ALDH1A1 (0.67) | HPGDHSD11B1ALDH1A1HSD17B10ALOX15 | |
| SCHEMBL1015456 | 0.81 | RAB9A (0.45) | HSD11B1ALDH1A1HSD17B10KDM6BKDM4A | |
| SCHEMBL1013058 | 0.81 | HSD11B1 (0.51) | HPGDHSD11B1ALDH1A1KDM4EKDM6B | |
| SCHEMBL1014328 | 0.74 | SMN1; SMN2 (0.42) | HPGDHSD11B1ALDH1A1HSD17B10KDM6B | |
| SCHEMBL1015260 | 0.73 | HSD11B1 (0.50) | HPGDHSD11B1ALDH1A1HSD17B10KDM6B | |
| SCHEMBL1018091 | 0.72 | HSD11B1 (0.46) | HSD11B1ALDH1A1ALOX15LMNAL3MBTL1 | |
| SCHEMBL1015936 | 0.72 | PTPN11 (0.47) | HSD11B1KDM4ELMNAMAPK1SMN1; SMN2 | |
| SCHEMBL2880540 | 0.72 | HPGD (0.69) | HPGDALDH1A1HSD17B10KDM4EALOX15 | |
| SCHEMBL13983005 | 0.72 | HPGD (1.00) | HPGDALDH1A1HSD17B10KDM4EALOX15 | |
| SCHEMBL1014300 | 0.71 | HSD11B1 (1.00) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271629-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | AstraZeneca AB (SE) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009130496-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009130496-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | WO | disclosed |
| US-20090264401-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-22 | — | — | US | disclosed |
| US-20090264401-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-22 | — | — | US | disclosed |
| US-20090264401-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | ASTRAZENECA AB (SE) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264401-A1 | SUBSTITUTED PYRIMIDIN-5-CARBOXAMIDES 281 | CYP2S1, HSD11B1, HSD3B1 | HPGD 54/4885HSD11B1 2/4885ALDH1A1 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.