Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.51 |
| ▸ | CCR2 | P41597 | 7/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10135620 | 0.84 | ROCK2 (0.46) | ROCK2CCR2ROCK1 | |
| SCHEMBL3314793 | 0.82 | ROCK2 (0.56) | ROCK2CCR2ROCK1 | |
| SCHEMBL3314802 | 0.82 | ROCK2 (0.56) | ROCK2CCR2ROCK1 | |
| SCHEMBL10135880 | 0.81 | LTA4H (0.53) | ROCK2CCR2ROCK1 | |
| SCHEMBL10135613 | 0.80 | MCHR1 (0.51) | ROCK2 | |
| SCHEMBL10135593 | 0.80 | MCHR1 (0.51) | ROCK2 | |
| SCHEMBL3313401 | 0.80 | ROCK2 (0.64) | ROCK2CCR2ROCK1 | |
| SCHEMBL3313404 | 0.80 | ROCK2 (0.64) | ROCK2CCR2ROCK1 | |
| SCHEMBL3315406 | 0.79 | ROCK2 (0.61) | ROCK2CCR2ROCK1 | |
| SCHEMBL3315415 | 0.79 | ROCK2 (0.61) | ROCK2CCR2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8951997-B2 | Substituted isoquinoline derivative | D. WESTERN THERAPEUTICS INSTITUTE, INC. (JP) | 2015-02-10 | — | — | US | disclosed |
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | D. WESTERN THERAPEUTICS INSTITUTE, INC (JP) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035159-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVE | SULT1A1, SULT1E1, SULT2A1 | ROCK2 1689/4885CCR2 752/4885ROCK1 1837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.