SCHEMBL10136299

SCHEMBL10136299

Cc1cc(C#N)cc(C(=O)NC(C)C2CC2)c1NC(=O)c1cc(CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)S(C)(=O)=O)nn1-c1ncccc1Cl

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 2/20 0.33
SLC2A3 P11169 2/20 0.33
SLC2A4 P14672 2/20 0.33
SLC2A2 P11168 1/20 0.33
KLKB1 P03952 3/20 0.31
DHODH Q02127 1/20 0.31
MALT1 Q9UDY8 1/20 0.31
EGLN1 Q9GZT9 1/20 0.31
TRPV1 Q8NER1 1/20 0.31
PTK2 Q05397 1/20 0.30
CYP3A4 P08684 2/20 0.30
UGCG Q16739 2/20 0.30
CCR5 P51681 1/20 0.30
MDM2 Q00987 1/20 0.30
CCR8 P51685 1/20 0.30
IDO1 P14902 1/20 0.30
GCK P35557 1/20 0.30
KCNH2 Q12809 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10136315 0.93 MDM2 (0.32) DHODHMALT1TRPV1PTK2CYP3A4
SCHEMBL10136639 0.93 SLC2A1 (0.34) SLC2A1SLC2A3SLC2A4SLC2A2DHODH
SCHEMBL10136614 0.91 CRHR1 (0.39) SLC2A1SLC2A3SLC2A4SLC2A2
SCHEMBL10136623 0.86 DHODH (0.35) DHODHCYP3A4UGCG
SCHEMBL12117374 0.84 SLC2A1 (0.37) SLC2A1SLC2A3SLC2A4SLC2A2EGLN1
SCHEMBL10136930 0.83 CRHR1 (0.40)
SCHEMBL12113192 0.81 OPRL1 (0.35) SLC2A1SLC2A3SLC2A4SLC2A2KLKB1
SCHEMBL11928309 0.81 SLC2A1 (0.33) SLC2A1SLC2A3SLC2A4SLC2A2KLKB1
SCHEMBL11928505 0.81 SLC2A1 (0.34) SLC2A1SLC2A3SLC2A4SLC2A2KLKB1
SCHEMBL12113367 0.81 SLC2A1 (0.34) SLC2A1SLC2A3SLC2A4SLC2A2KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582688-B1 ANTHRANILIC ACID DIAMIDE DERIVATIVES BAYER IP GMBH (DE) 2015-10-07 EP disclosed
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES DDT, QDPR, ANTXR2 SLC2A1 3127/4885SLC2A3 3314/4885SLC2A4 3392/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.