SCHEMBL10136623

SCHEMBL10136623

Cc1cc(Cl)cc(C(=O)NC(C)C)c1NC(=O)c1cc(CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)S(C)(=O)=O)nn1-c1ncccc1Cl

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.35
TACR1 P25103 4/20 0.33
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
CYP3A4 P08684 3/20 0.31
UGCG Q16739 3/20 0.31
CAPN1 P07384 1/20 0.31
PSMB5 P28074 1/20 0.30
ALDH1A1 P00352 1/20 0.30
MRGPRX4 Q96LA9 1/20 0.30
CETP P11597 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10136315 0.93 MDM2 (0.32) DHODHTACR1MEN1KMT2ACYP3A4
SCHEMBL10136639 0.93 SLC2A1 (0.34) DHODHTACR1CETP
SCHEMBL10136930 0.90 CRHR1 (0.40)
SCHEMBL10136233 0.89 TACR1 (0.33) DHODHTACR1CYP3A4UGCGCAPN1
SCHEMBL10136610 0.88 DHODH (0.33) DHODHTACR1KMT2ACYP3A4UGCG
SCHEMBL10136641 0.88 ALDH1A1 (0.34) DHODHTACR1CYP3A4UGCGCAPN1
SCHEMBL10136299 0.86 SLC2A1 (0.33) DHODHCYP3A4UGCG
SCHEMBL10118322 0.85 ALDH1A1 (0.35) DHODHALDH1A1
SCHEMBL10136217 0.84 GRM4 (0.36) DHODHMEN1KMT2ACAPN1ALDH1A1
SCHEMBL10136642 0.84 ALDH1A1 (0.35) DHODHCYP3A4UGCGCAPN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582688-B1 ANTHRANILIC ACID DIAMIDE DERIVATIVES BAYER IP GMBH (DE) 2015-10-07 EP disclosed
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES DDT, QDPR, ANTXR2 DHODH 197/4885TACR1 591/4885MEN1 1583/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.