SCHEMBL10136614

SCHEMBL10136614

Cc1cc(C#N)cc(C(=O)NC2CC2)c1NC(=O)c1cc(CN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)S(C)(=O)=O)nn1-c1ncccc1Cl

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CRHR1 P34998 14/20 0.39
MAPK13 O15264 1/20 0.36
MAPK12 P53778 1/20 0.36
MAPK11 Q15759 1/20 0.36
MAPK14 Q16539 1/20 0.36
CRHR2 Q13324 2/20 0.35
SLC2A1 P11166 1/20 0.34
SLC2A2 P11168 1/20 0.34
SLC2A3 P11169 1/20 0.34
SLC2A4 P14672 1/20 0.34
ELANE P08246 1/20 0.33
RORC P51449 1/20 0.33
NTRK1 P04629 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10136930 0.93 CRHR1 (0.40) CRHR1MAPK13MAPK12MAPK11MAPK14
SCHEMBL10136299 0.91 SLC2A1 (0.33) SLC2A1SLC2A2SLC2A3SLC2A4
SCHEMBL10136639 0.90 SLC2A1 (0.34) SLC2A1SLC2A2SLC2A3SLC2A4
SCHEMBL10136315 0.83 MDM2 (0.32) CRHR1
SCHEMBL12117036 0.83 CRHR1 (0.39) CRHR1MAPK13MAPK12MAPK11MAPK14
SCHEMBL10136623 0.83 DHODH (0.35)
SCHEMBL10075531 0.80 CRHR1 (0.37) CRHR1MAPK13MAPK12MAPK11MAPK14
SCHEMBL12113196 0.80 MAPK14 (0.38) CRHR1MAPK13MAPK12MAPK11MAPK14
SCHEMBL10075532 0.80 CRHR1 (0.36) CRHR1MAPK13MAPK12MAPK11MAPK14
SCHEMBL12113385 0.80 CRHR1 (0.36) CRHR1MAPK13MAPK12MAPK11MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2582688-B1 ANTHRANILIC ACID DIAMIDE DERIVATIVES BAYER IP GMBH (DE) 2015-10-07 EP disclosed
US-8791139-B2 Anthranilic diamide derivatives BAYER CROPSCIENCE AG (DE) 2014-07-29 US disclosed
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2012-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120015980-A1 ANTHRANILIC DIAMIDE DERIVATIVES DDT, QDPR, ANTXR2 CRHR1 4128/4885MAPK13 3441/4885MAPK12 3047/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.