SCHEMBL10137818

SCHEMBL10137818

CCN1/C(=C/C=C/C=C/C2=[N+](CC)c3ccccc3C2(C)C)C(C)(C)c2ccccc21

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.84
KMT2A Q03164 5/20 0.84
MAPT P10636 4/20 0.84
NPC1 O15118 3/20 0.84
RAB9A P51151 3/20 0.84
SMN1; SMN2 Q16637 3/20 0.84
NPSR1 Q6W5P4 3/20 0.84
HTT P42858 3/20 0.84
BLM P54132 3/20 0.84
USP2 O75604 2/20 0.84
LMNA P02545 2/20 0.84
POLB P06746 2/20 0.84
THRB P10828 2/20 0.84
PKM P14618 2/20 0.84
XBP1 P17861 2/20 0.84
RECQL P46063 2/20 0.84
S1PR2 O95136 1/20 0.84
ALPG P10696 1/20 0.84
CRHBP P24387 1/20 0.84
CRHR2 Q13324 1/20 0.84

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10036027 1.00 MEN1 (0.84) MEN1KMT2AMAPTNPC1RAB9A
Iodide SCHEMBL29461678 0.99 MEN1 (0.83) MEN1KMT2AMAPTNPC1RAB9A
Iodide SCHEMBL29461580 0.99 MEN1 (0.83) MEN1KMT2AMAPTNPC1RAB9A
Iodide SCHEMBL10864237 0.99 MEN1 (0.83) MEN1KMT2AMAPTNPC1RAB9A
Iodide SCHEMBL10864242 0.99 MEN1 (0.83) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL8603487 0.96 MEN1 (0.92) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL13873490 0.96 MEN1 (0.92) MEN1KMT2AMAPTNPC1RAB9A
SCHEMBL10137808 0.96 MEN1 (0.92) MEN1KMT2AMAPTNPC1RAB9A
Iodide SCHEMBL31018273 0.94 MEN1 (0.90) MEN1KMT2AMAPTNPC1RAB9A
Iodide SCHEMBL29419520 0.94 MEN1 (0.90) MEN1KMT2AMAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160263249-A1 NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF BETH ISRAEL DEACONESS MEDICAL CENTER (US) 2016-09-15 US disclosed
US-20160263249-A1 NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF BETH ISRAEL DEACONESS MEDICAL CENTER (US) 2016-09-15 US disclosed
WO-2015066290-A1 NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF BETH ISRAEL DEACONESS MEDICAL CENTER (US) 2015-05-07 WO disclosed
US-8889887-B2 Pentamethine cyanine fluorescent dyes, preparation methods and uses thereof DALIAN UNIVERSITY OF TECHNOLOGY (CN) 2014-11-18 US disclosed
US-8771642-B2 Active particles for bio-analytical applications and methods for their preparation Alma Mater Studiorum—Universita' di Bologna (IT) 2014-07-08 US disclosed
US-8771642-B2 Active particles for bio-analytical applications and methods for their preparation Alma Mater Studiorum—Universita' di Bologna (IT) 2014-07-08 US disclosed
EP-1781675-B1 PHOSPHONATE FLUORESCENT DYES AND CONJUGATES EPOCH BIOSCIENCES INC (US) 2014-03-26 EP disclosed
US-8389745-B2 Phosphonate fluorescent dyes and conjugates ELITECH HOLDING B.V. (NL) 2013-03-05 US disclosed
US-20120116079-A1 PHOSPHONATE FLUORESCENT DYES AND CONJUGATES ELITECHGROUP MDX LLC 2012-05-10 US disclosed
US-20110274621-A1 Active Particles for Bio-Analytical Applications and Methods for Their Preparation ALMA MATER STUDIORUM-UNIVERSITA'DI BOLOGNA (IT) 2011-11-10 US disclosed
US-8008522-B2 Phosphonate fluorescent dyes and conjugates ELITECH HOLDING B.V. (NL) 2011-08-30 US disclosed
US-20100261903-A1 PHOSPHONATE FLUORESCENT DYES AND CONJUGATES ELITECHGROUP MDX LLC 2010-10-14 US disclosed
US-7767834-B2 Phosphonylated fluorescent dyes and conjugates ELITECH HOLDING B.V. (NL) 2010-08-03 US disclosed
US-7671218-B2 Phosphonate fluorescent dyes and conjugates Elitech Holdings B.V. (NL) 2010-03-02 US disclosed
WO-2010013137-A1 ACTIVE PARTICLES FOR BIO-ANALYTICAL APPLICATIONS AND METHODS FOR PREPARATION THEREOF ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (IT) 2010-02-04 WO disclosed
WO-2010013136-A2 ACTIVE PARTICLES FOR BIO-ANALYTICAL APPLICATIONS AND METHODS FOR THEIR PREPARATION ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA (IT) 2010-02-04 WO disclosed
US-20080207887-A1 PHOSPHONYLATED FLUORESCENT DYES AND CONJUGATES EPOCH BIOSCIENCES, INC. (US) 2008-08-28 US disclosed
US-20070231742-A1 Optical Information-Recording Medium FUJIFILM CORPORATION (JP) 2007-10-04 US disclosed
US-20070231742-A1 Optical Information-Recording Medium FUJIFILM CORPORATION (JP) 2007-10-04 US disclosed
US-20070172832-A1 Phosphonate fluorescent dyes and conjugates EPOCH BIOSCIENCES, INC. (US) 2007-07-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100261903-A1 PHOSPHONATE FLUORESCENT DYES AND CONJUGATES PHOSPHO1, PFAS, PHPT1 MEN1 1647/4885KMT2A 3091/4885MAPT 1477/4885
US-20080207887-A1 PHOSPHONYLATED FLUORESCENT DYES AND CONJUGATES PHOSPHO1, PFAS, PHPT1 MEN1 1539/4885KMT2A 3036/4885MAPT 1921/4885
US-20070172832-A1 Phosphonate fluorescent dyes and conjugates PHOSPHO1, PFAS, PHPT1 MEN1 1647/4885KMT2A 3091/4885MAPT 1477/4885
US-20110274621-A1 Active Particles for Bio-Analytical Applications and Methods for Their Preparation PHOSPHO1, LIPA, ALG1 MEN1 294/4885KMT2A 3433/4885MAPT 3089/4885
US-20160263249-A1 NEAR-INFRARED FLUORESCENT CONTRAST BIOIMAGING AGENTS AND METHODS OF USE THEREOF CD68, MSR1, CD47 MEN1 498/4885KMT2A 4412/4885MAPT 3284/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.