Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29634290 | 0.81 | PGR (0.60) | LMNAPGRMAPTSIRT2DAO | |
| SCHEMBL2718464 | 0.81 | PGR (0.60) | LMNAPGRMAPTSIRT2DAO | |
| SCHEMBL10139723 | 0.81 | KMT2A (0.47) | TP53SIRT2KDM4EGAA | |
| SCHEMBL1857924 | 0.74 | LMNA (0.57) | LMNATP53MAOBMAPTPDE3B | |
| SCHEMBL13233690 | 0.74 | BRPF1 (0.46) | LMNATP53MAPTKDM4EGAA | |
| SCHEMBL10139240 | 0.72 | GRIA1 (0.47) | MAPTPDE3BPDE3AKDM4EGAA | |
| SCHEMBL3263393 | 0.72 | DAO (0.66) | LMNATP53PGRMAOBMAPT | |
| SCHEMBL26666463 | 0.71 | LMNA (0.53) | LMNATP53PGRMAOBMAPT | |
| SCHEMBL13672562 | 0.71 | LMNA (0.53) | LMNATP53PGRMAOBMAPT | |
| SCHEMBL25318060 | 0.70 | LMNA (0.56) | LMNATP53PGRMAOBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012059932-A1 | 2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-10 | — | — | WO | disclosed |