Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | GLA | P06280 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10139260 | 0.87 | SIRT2 (0.51) | KMT2ARAB9AMEN1ALDH1A1GAA | |
| SCHEMBL10138692 | 0.81 | LMNA (0.47) | GAAKDM4ESIRT2TP53 | |
| SCHEMBL10169863 | 0.80 | KMT2A (0.55) | KMT2ARAB9AMEN1ALDH1A1GAA | |
| SCHEMBL10138713 | 0.79 | KMT2A (0.51) | KMT2ARAB9AMEN1ALDH1A1GAA | |
| SCHEMBL19705040 | 0.76 | PTGER4 (0.55) | KMT2ARAB9AMEN1ALDH1A1GAA | |
| SCHEMBL740232 | 0.75 | RAB9A (0.68) | KMT2ARAB9AMEN1ALDH1A1HPGD | |
| SCHEMBL5243499 | 0.72 | KMT2A (0.48) | KMT2ARAB9AMEN1ALDH1A1GAA | |
| SCHEMBL20569799 | 0.71 | SIRT2 (0.47) | KMT2AMEN1ALDH1A1KDM4ESIRT2 | |
| SCHEMBL17845479 | 0.70 | GRIN1 (0.55) | KMT2ARAB9AMEN1ALDH1A1GAA | |
| SCHEMBL551807 | 0.70 | RAB9A (0.43) | KMT2ARAB9AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012059932-A1 | 2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-10 | — | — | WO | disclosed |