SCHEMBL10139147

SCHEMBL10139147

NC(=O)c1cnn(-c2ccc(N)cc2)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP4K4 O95819 1/20 0.56
HPGDS O60760 1/20 0.53
ALKBH2 Q6NS38 1/20 0.53
MAPKAPK2 P49137 2/20 0.52
MAPT P10636 7/20 0.44
NPC1 O15118 6/20 0.44
RAB9A P51151 6/20 0.44
HPGD P15428 3/20 0.44
NFKB1 P19838 2/20 0.44
NFKB2 Q00653 2/20 0.44
RELA Q04206 2/20 0.44
HTT P42858 2/20 0.44
SMN1; SMN2 Q16637 3/20 0.43
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 2/20 0.43
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
PARP10 Q53GL7 1/20 0.41
ESRRA P11474 1/20 0.40
HSD11B1 P28845 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27680338 0.86 ALKBH2 (0.72) MAP4K4HPGDSALKBH2MAPTNPC1
SCHEMBL20504240 0.85 MAPT (0.59) MAP4K4HPGDSALKBH2MAPKAPK2MAPT
SCHEMBL3916180 0.85 MAP4K4 (0.55) MAP4K4HPGDSALKBH2MAPKAPK2MAPT
SCHEMBL2190049 0.84 ALKBH2 (0.74) MAP4K4HPGDSALKBH2MAPKAPK2MAPT
SCHEMBL27933760 0.84 MAP4K4 (0.55) MAP4K4HPGDSALKBH2MAPKAPK2MAPT
SCHEMBL7322694 0.81 MAPKAPK2 (0.48) MAP4K4HPGDSALKBH2MAPKAPK2MAPT
SCHEMBL30132085 0.81 HPGDS (0.51) MAP4K4HPGDSALKBH2MAPKAPK2MAPT
SCHEMBL4481678 0.81 HPGDS (0.51) MAP4K4HPGDSALKBH2MAPKAPK2MAPT
SCHEMBL4261591 0.79 HPGDS (0.45) MAP4K4HPGDSALKBH2MAPKAPK2MAPT
SCHEMBL5963038 0.79 PARP10 (0.57) MAP4K4HPGDSALKBH2MAPKAPK2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012059932-A1 2, 4 -DIAMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2012-05-10 WO disclosed