Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MC4R | P32245 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL538179 | 0.89 | HSD17B10 (0.55) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL538231 | 0.88 | ALDH1A1 (0.54) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL2904843 | 0.80 | CSF1R (0.63) | MEN1KMT2AMAPTGAAL3MBTL1 | |
| SCHEMBL12143424 | 0.75 | ALOX15 (0.57) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL23701351 | 0.74 | MEN1 (0.56) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL2912835 | 0.74 | KCNH2 (0.63) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL2912345 | 0.74 | CSF1R (0.71) | MEN1KMT2AMAPTGAAL3MBTL1 | |
| SCHEMBL22717265 | 0.73 | PKM (0.55) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL12844576 | 0.73 | ALOX15 (0.53) | ALDH1A1KDM4EHSD17B10HPGDMEN1 | |
| SCHEMBL16235611 | 0.73 | PIK3CA (0.60) | ALDH1A1KDM4EHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166852-B1 | THERAPEUTIC PYRAZOLOQUINOLINE DERIVATIVES | HELICON THERAPEUTICS INC (US) | 2012-02-08 | — | — | EP | disclosed |