Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | PREP | P48147 | 4/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13596273 | 0.86 | CHRM2 (0.45) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL10139209 | 0.86 | CHRM2 (0.45) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL10139215 | 0.85 | CHRM2 (0.42) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL13632125 | 0.85 | CHRNB2 (0.59) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL668996 | 0.85 | CHRM2 (0.44) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL2495907 | 0.85 | CHRM2 (0.44) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL10139208 | 0.81 | CHRNB2 (0.41) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL10138694 | 0.80 | USP30 (0.40) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL1721264 | 0.79 | GPR119 (0.48) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL15024843 | 0.77 | WNT3A (0.42) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012024615-A1 | NICOTINIC RECEPTOR COMPOUNDS | RESEARCH TRIANGLE INSTITUTE (US) | 2012-02-23 | — | — | WO | disclosed |