Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.43 |
| ▸ | PREP | P48147 | 3/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10139209 | 0.89 | CHRM2 (0.45) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL2495907 | 0.88 | CHRM2 (0.44) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL13632125 | 0.88 | CHRNB2 (0.59) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL668996 | 0.88 | CHRM2 (0.44) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL10139726 | 0.86 | CHRM2 (0.42) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL10139215 | 0.86 | CHRM2 (0.42) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL10139208 | 0.84 | CHRNB2 (0.41) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL1721264 | 0.82 | GPR119 (0.48) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL10138694 | 0.81 | USP30 (0.40) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 | |
| SCHEMBL15024843 | 0.80 | WNT3A (0.42) | CHRM2CHRM1CHRM3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318490-A1 | COMPOUNDS AND METHODS FOR PROMOTING SMOKING CESSATION | RESEARCH TRIANGLE INSITUTE (US) | 2009-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318490-A1 | COMPOUNDS AND METHODS FOR PROMOTING SMOKING CESSATION | BHMT2, CBS, NNMT | CHRM2 420/4885CHRM1 711/4885CHRM3 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.