Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ECE1 | P42892 | 1/20 | 0.34 |
| ▸ | MAP3K13 | O43283 | 4/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1017739 | 0.80 | GPR119 (0.44) | FAAHRORCHDAC1GPR119 | |
| SCHEMBL11963475 | 0.72 | MAP3K13 (0.39) | ECE1MAP3K13MAP3K12MAPTLMNA | |
| SCHEMBL8435167 | 0.70 | GBA2 (0.43) | GBA2L3MBTL1ECE1LMNAPOLB | |
| SCHEMBL1365825 | 0.69 | HDAC1 (0.42) | MAP3K13MAP3K12HDAC1GPR119 | |
| SCHEMBL22346683 | 0.67 | GBA2 (0.43) | GBA2ECE1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL29639440 | 0.67 | GBA2 (0.50) | GBA2KDM4EMAPK1L3MBTL1ECE1 | |
| SCHEMBL1367540 | 0.66 | HDAC1 (0.41) | GBA2MAP3K13MAP3K12HDAC1GPR119 | |
| SCHEMBL20139230 | 0.66 | MAPT (0.51) | MAPTLMNAALDH1A1 | |
| SCHEMBL19211049 | 0.65 | RARA (0.36) | KDM4EMAPK1L3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL1017524 | 0.65 | RORC (0.44) | FAAHRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2271649-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | Wyeth LLC (US) | 2011-01-12 | — | — | EP | disclosed |
| WO-2009108838-A1 | BRIDGED, BICYCLIC HETEROCYCLIC OR SPIRO BICYCLIC HETEROCYCLIC DERIVATIVES OF PYRAZOLO[1,5-A]PYRIMIDINES, METHODS FOR PREPARATION AND USES THEREOF | WYETH (US) | 2009-09-03 | — | — | WO | disclosed |