SCHEMBL10140300

SCHEMBL10140300

O=C(CI)NCCNC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 5/20 0.67
▸ PKM P14618 2/20 0.64
▸ MEN1 O00255 1/20 0.64
▸ ABL1 P00519 1/20 0.64
▸ LMNA P02545 1/20 0.64
▸ IDE P14735 1/20 0.64
▸ MAPK1 P28482 1/20 0.64
▸ KMT2A Q03164 1/20 0.64
▸ RIN1 Q13671 1/20 0.64
▸ L3MBTL1 Q9Y468 1/20 0.64
▸ CA12 O43570 4/20 0.62
▸ CA1 P00915 4/20 0.62
▸ CA2 P00918 4/20 0.62
▸ CA9 Q16790 4/20 0.62
▸ HLCS P50747 3/20 0.56
▸ F2 P00734 1/20 0.56
▸ PRSS1 P07477 1/20 0.56
▸ PRSS2 P07478 1/20 0.56
▸ PRSS3 P35030 1/20 0.56
▸ TPSAB1 Q15661 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2032873 1.00 TDP1 (0.67) TDP1PKMMEN1ABL1LMNA
SCHEMBL1096616 1.00 TDP1 (0.67) TDP1PKMMEN1ABL1LMNA
SCHEMBL1035258 0.95 TDP1 (0.71) TDP1PKMMEN1ABL1LMNA
SCHEMBL10140209 0.95 TDP1 (0.71) TDP1PKMMEN1ABL1LMNA
SCHEMBL9412852 0.94 TDP1 (0.74) TDP1PKMMEN1ABL1LMNA
SCHEMBL13297163 0.92 F2 (0.68) TDP1PKMMEN1ABL1LMNA
SCHEMBL13315713 0.92 F2 (0.68) TDP1PKMMEN1ABL1LMNA
SCHEMBL12845112 0.92 F2 (0.68) TDP1PKMMEN1ABL1LMNA
SCHEMBL142626 0.91 TDP1 (0.62) TDP1PKMMEN1ABL1LMNA
SCHEMBL12020222 0.91 TDP1 (0.62) TDP1PKMMEN1ABL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2552202-B1 METHODS AND COMPOSITIONS FOR WEIGHT LOSS SDG INC (US) 2023-07-26 — — EP disclosed
EP-2552202-B1 METHODS AND COMPOSITIONS FOR WEIGHT LOSS SDG INC (US) 2023-07-26 — — EP disclosed
US-11517529-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2022-12-06 — — US disclosed
EP-3391876-B1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG INC (US) 2021-03-10 — — EP disclosed
US-20200405638-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS SDG INC (US) 2020-12-31 — — US disclosed
US-10751418-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2020-08-25 — — US disclosed
US-20200261363-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG INC (US) 2020-08-20 — — US disclosed
US-10568835-B2 Orally bioavailable lipid-based constructs SDG, INC. (US) 2020-02-25 — — US disclosed
US-10463616-B2 Lipid construct for delivery of insulin to a mammal SDG, INC. (US) 2019-11-05 — — US disclosed
US-20190054021-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL SDG, INC. 2019-02-21 — — US disclosed
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-12-09 — — US disclosed
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-12-09 — — US disclosed
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, INC. 2010-05-27 — — US disclosed
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL SDG, INC. 2010-05-27 — — US disclosed
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-04-01 — — US disclosed
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs SDG, INC. 2010-04-01 — — US disclosed
US-20090087479-A1 Orally bioavailable lipid-based constructs SDG, INC. ( AN OHIO CORPORATION) (US) 2009-04-02 — — US disclosed
US-20090087479-A1 Orally bioavailable lipid-based constructs SDG, INC. ( AN OHIO CORPORATION) (US) 2009-04-02 — — US disclosed
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal SDG, INC. 2007-09-20 — — US disclosed
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal SDG, INC. 2007-09-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070218117-A1 Supra molecular construct for delivery of interferon to a mammal HAVCR2, IFNAR1, MSR1 TDP1 4728/4885PKM 3916/4885MEN1 4097/4885
US-10568835-B2 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4819/4885PKM 4050/4885MEN1 966/4885
US-20100080773-A1 Orally Bioavailable Lipid-Based Constructs FABP2, FABP1, LIPC TDP1 4742/4885PKM 3358/4885MEN1 1477/4885
US-20100129428-A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL HAVCR2, IFNAR1, IFNG TDP1 4713/4885PKM 4040/4885MEN1 4095/4885
US-20100310599-A1 Orally Bioavailable Lipid-Based Constructs FABP2, LIPC, FABP6 TDP1 4650/4885PKM 1868/4885MEN1 1077/4885
US-11517529-B2 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4819/4885PKM 4050/4885MEN1 966/4885
US-20190054021-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL INSR, IAPP, GPR119 TDP1 4882/4885PKM 3371/4885MEN1 1400/4885
US-20200405638-A1 ORALLY BIOAVAILABLE LIPID-BASED CONSTRUCTS FABP2, FABP1, FABP6 TDP1 4819/4885PKM 4050/4885MEN1 966/4885
US-20090087479-A1 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4757/4885PKM 3153/4885MEN1 1343/4885
US-20200261363-A1 LIPID CONSTRUCT FOR DELIVERY OF INSULIN TO A MAMMAL INSR, IAPP, GPR119 TDP1 4882/4885PKM 3371/4885MEN1 1400/4885
US-10463616-B2 Lipid construct for delivery of insulin to a mammal INSR, IAPP, GPR119 TDP1 4882/4885PKM 3371/4885MEN1 1400/4885
US-10751418-B2 Orally bioavailable lipid-based constructs FABP2, FABP1, FABP6 TDP1 4819/4885PKM 4050/4885MEN1 966/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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