SCHEMBL10140559

SCHEMBL10140559

Cc1ccc(N)c(NN)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.54
ALOX15 P16050 2/20 0.54
CYP3A4 P08684 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
TP53 P04637 1/20 0.54
THRB P10828 1/20 0.54
ALDH1A1 P00352 4/20 0.46
NPC1 O15118 2/20 0.44
MAPT P10636 2/20 0.44
RAB9A P51151 2/20 0.44
PKM P14618 1/20 0.44
MAPK1 P28482 1/20 0.44
ATM Q13315 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
HSD17B10 Q99714 1/20 0.43
CA1 P00915 1/20 0.41
GAA P10253 2/20 0.41
TSHR P16473 1/20 0.41
RAPGEF4 Q8WZA2 1/20 0.38
KDM4E B2RXH2 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7330774 0.81 TDP1 (0.54) TDP1ALOX15CYP3A4SMN1; SMN2TP53
SCHEMBL14218921 0.81 TDP1 (0.54) TDP1ALOX15CYP3A4SMN1; SMN2TP53
SCHEMBL14610894 0.79 TDP1 (0.52) TDP1ALOX15CYP3A4SMN1; SMN2TP53
SCHEMBL30951588 0.78 RAPGEF4 (0.54) TDP1TP53ALDH1A1RAB9AHSD17B10
SCHEMBL838148 0.78 RAPGEF4 (0.54) TDP1TP53ALDH1A1RAB9AHSD17B10
SCHEMBL8338686 0.77 TDP1 (0.50) TDP1ALOX15CYP3A4SMN1; SMN2TP53
Hydrochloric Acid SCHEMBL839579 0.76 RAPGEF4 (0.52) TDP1SMN1; SMN2TP53ALDH1A1NPC1
Hydrochloric Acid SCHEMBL31082291 0.76 RAPGEF4 (0.52) TDP1SMN1; SMN2TP53ALDH1A1NPC1
SCHEMBL2014730 0.76 LMNA (0.50) TDP1ALOX15CYP3A4SMN1; SMN2TP53
SCHEMBL6707715 0.76 TDP1 (0.48) TDP1ALOX15CYP3A4SMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3611174-B1 [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR MEDSHINE DISCOVERY INC (CN) 2022-06-08 EP disclosed
EP-3445752-B1 HISTONE DEMETHYLASE INHIBITORS CELGENE QUANTICEL RES INC (US) 2022-01-12 EP disclosed
EP-3611174-A1 [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE DERIVATIVE AS A2A RECEPTOR INHIBITOR Medshine Discovery Inc. (CN) 2020-02-19 EP disclosed
EP-3511330-A1 SYNTHETIC INTERMEDIATE USEFUL IN THE PREPARATION OF TRIAZOLOPYRIDINE C-MET INHIBITORS Hutchison Medipharma Limited (CN) 2019-07-17 EP disclosed
WO-2019046666-A1 HERBICIDAL COMPOSITIONS CONTAINING PYRIDINE CARBOXYLIC ACIDS OR DERIVATIVES THEREOF, WITH GLYPHOSATE OR GLUFOSINATE, OR DERIVATIVES THEREOF DOW AGROSCIENCES LLC (US) 2019-03-07 WO disclosed
WO-2019046667-A1 HERBICIDAL COMPOSITIONS CONTAINING PYRIDINE CARBOXYLIC ACIDS OR DERIVATIVES THEREOF, WITH PDS AND VLCFA INHIBITORS, OR DERIVATIVES THEREOF DOW AGROSCIENCES LLC (US) 2019-03-07 WO disclosed
EP-3128368-B1 CHEMICALLY AMPLIFIED POSITIVE RESIST COMPOSITION AND PATTERN FORMING PROCESS SHINETSU CHEMICAL CO (JP) 2018-01-24 EP disclosed
EP-2864292-B1 NEPRILYSIN INHIBITORS THERAVANCE BIOPHARMA R&D IP LLC (US) 2017-04-12 EP disclosed
EP-3128368-A1 CHEMICALLY AMPLIFIED POSITIVE RESIST COMPOSITION AND PATTERN FORMING PROCESS Shin-Etsu Chemical Co., Ltd. (JP) 2017-02-08 EP disclosed
WO-2012021704-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2012-02-16 WO disclosed
WO-2011091417-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2011-07-28 WO disclosed
WO-2011081918-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC (US) 2011-07-07 WO disclosed
WO-2011031934-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. (US) 2011-03-17 WO disclosed
WO-2008047883-A1 PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-04-24 WO disclosed