Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30951588 | 1.00 | RAPGEF4 (0.54) | RAPGEF4ALDH1A1GAAHTTKDM4E | |
| Hydrochloric Acid SCHEMBL31082291 | 0.98 | RAPGEF4 (0.52) | RAPGEF4ALDH1A1GAAHTTKDM4E | |
| Hydrochloric Acid SCHEMBL839579 | 0.98 | RAPGEF4 (0.52) | RAPGEF4ALDH1A1GAAHTTKDM4E | |
| SCHEMBL1010790 | 0.80 | RAPGEF4 (0.56) | RAPGEF4ALDH1A1GAAHTTTDP1 | |
| SCHEMBL29401670 | 0.80 | RAPGEF4 (0.56) | RAPGEF4ALDH1A1GAAHTTTDP1 | |
| SCHEMBL9224102 | 0.79 | GAA (0.65) | RAPGEF4ALDH1A1GAAHTTKDM4E | |
| SCHEMBL29196035 | 0.79 | RAPGEF4 (0.71) | RAPGEF4ALDH1A1GAAHTTKDM4E | |
| SCHEMBL10385157 | 0.78 | MAPT (0.41) | RAPGEF4ALDH1A1GAAHTTKDM4E | |
| Hydrochloric Acid SCHEMBL30977785 | 0.78 | RAPGEF4 (0.54) | RAPGEF4ALDH1A1GAAHTTTDP1 | |
| Hydrochloric Acid SCHEMBL1012671 | 0.78 | RAPGEF4 (0.54) | RAPGEF4ALDH1A1GAAHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918052-B1 | Improved polymeric mdi color | BAYER AG (US) | 2003-05-28 | — | — | EP | claimed |
| US-20250011319-A1 | SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF | LOMOND THERAPEUTICS, INC. | 2025-01-09 | — | — | US | disclosed |
| US-11999734-B2 | Compounds and compositions for the treatment of cystic fibrosis | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2024-06-04 | — | — | US | disclosed |
| CN-118076605-A | Substituted 1H-pyrazolo [4,3-c ] quinolines, methods of preparation and uses thereof | 洛蒙治疗公司 | 2024-05-24 | — | — | CN | disclosed |
| EP-3820867-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2023-09-13 | — | — | EP | disclosed |
| CN-116655536-A | Class N 1 -aryl-3-fluoroalkyl-5-fluoropyrazole compound, and preparation method and application thereof | 天津大学 | 2023-08-29 | — | — | CN | disclosed |
| CN-115707334-A | Method for rubber regeneration | A·A·斯拉涅夫斯基 | 2023-02-17 | — | — | CN | disclosed |
| CN-112409203-B | Method for simultaneously synthesizing phenylhydrazine salt and pyruvic acid or glyoxylic acid | 帕潘纳(北京)科技有限公司 | 2022-10-25 | — | — | CN | disclosed |
| US-20210292324-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | ISTITUTO GIANNINA GASLINI (IT) | 2021-09-23 | — | — | US | disclosed |
| EP-3820867-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | Fondazione Istituto Italiano di Tecnologia (IT) | 2021-05-19 | — | — | EP | disclosed |
| EP-1042319-A1 | DIHYDROBENZOFURANS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| EP-0971901-A1 | PHTHALAZINONES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2000-01-19 | — | — | EP | disclosed |
| WO-1999031090-A1 | DIHYDROBENZOFURANS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |
| WO-1998031674-A1 | PHTHALAZINONES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-07-23 | — | — | WO | disclosed |
| EP-0486900-B1 | Process for the preparation of indoles | BAYER AG (DE) | 1996-09-04 | — | — | EP | disclosed |
| US-5179211-A | PROCESS FOR THE PREPARATION OF INDOLES | BAYER AKTIENGESELLSCHAFT (DE) | 1993-01-12 | — | — | US | disclosed |
| EP-0486900-A2 | Process for the preparation of indoles | BAYER AG (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-5017454-A | Electron transfer compound containing pyrazole ring | FUJI PHOTO FILM CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| US-4325962-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTIDYRETICS | BYK-GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-04-20 | — | — | US | disclosed |
| US-4146721-A | ANALGESICS, ANTIINFLAMMATORY AGENTS AND ANTIPYRETICS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1979-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999734-B2 | Compounds and compositions for the treatment of cystic fibrosis | CFTR, ABCB11, ABCC5 | RAPGEF4 2093/4885ALDH1A1 2608/4885GAA 660/4885 |
| US-20250011319-A1 | SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF | FLT3, PDXK, PHKG1 | RAPGEF4 3198/4885ALDH1A1 2059/4885GAA 2598/4885 |
| US-20210292324-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, ABCB11, ABCC5 | RAPGEF4 2093/4885ALDH1A1 2608/4885GAA 660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.