SCHEMBL10142592

SCHEMBL10142592

c1cnc(-c2cccc(-c3ccoc3)n2)nc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 1/20 0.44
CYP1A2 P05177 8/20 0.42
CYP2D6 P10635 8/20 0.42
MEN1 O00255 7/20 0.42
KMT2A Q03164 7/20 0.42
CYP2C19 P33261 7/20 0.42
USP2 O75604 6/20 0.42
CYP3A4 P08684 6/20 0.42
MAPT P10636 5/20 0.42
KDM4E B2RXH2 4/20 0.42
TSHR P16473 1/20 0.42
ALDH1A1 P00352 7/20 0.42
ALOX15 P16050 6/20 0.42
HSD17B10 Q99714 6/20 0.42
TP53 P04637 3/20 0.42
PPARA Q07869 1/20 0.42
LMNA P02545 4/20 0.40
TDP1 Q9NUW8 4/20 0.40
CLK4 Q9HAZ1 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29620537 0.79 KMT2A (0.52) CYP1A2CYP2D6MEN1KMT2ACYP2C19
SCHEMBL18952015 0.78 CYP1A2 (0.50) CYP1A2CYP2D6MEN1KMT2ACYP2C19
SCHEMBL2099096 0.77 KDM4E (0.52) CYP1A2CYP2D6MEN1KMT2ACYP2C19
SCHEMBL3890399 0.75 RAB9A (0.70) CYP1A2MEN1KMT2AMAPTKDM4E
SCHEMBL6981942 0.74 CCR1 (0.56) HTR7CYP1A2CYP2D6MEN1KMT2A
SCHEMBL2773632 0.74 ASIC3 (0.57) HTR7CYP2D6MEN1KMT2ACYP2C19
SCHEMBL26685381 0.74 HTR7 (0.47) HTR7CYP1A2CYP2D6MEN1KMT2A
SCHEMBL6847836 0.73 CLK4 (0.44) CYP1A2CYP2D6MEN1KMT2ACYP2C19
SCHEMBL15297122 0.71 GRM5 (0.38) CYP1A2MEN1KMT2ACYP2C19CYP3A4
SCHEMBL1644468 0.70 HSP90AA1 (0.58) MAPTKDM4EALDH1A1SMN1; SMN2HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012052412-A1 NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AG (DE) 2012-04-26 WO disclosed