Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 5/20 | 0.49 |
| ▸ | PDE4A | P27815 | 5/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10143833 | 0.86 | CACNA1B (0.44) | CACNA1BHTR4HRH1 | |
| SCHEMBL14216100 | 0.85 | HRH2 (0.45) | CACNA1BHTR4HRH1 | |
| SCHEMBL10143824 | 0.82 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DHTR4 | |
| SCHEMBL10143788 | 0.82 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DHTR4 | |
| SCHEMBL375994 | 0.75 | CACNA1B (0.49) | CACNA1BAAK1 | |
| SCHEMBL13543471 | 0.72 | HTR4 (0.45) | HTR4KCNH2 | |
| SCHEMBL12426368 | 0.72 | HPGDS (0.47) | HTR4MEN1KMT2A | |
| SCHEMBL13543713 | 0.72 | TAS1R3 (0.42) | PDE4APDE4BPDE4CPDE4DHTR4 | |
| SCHEMBL14066410 | 0.71 | CACNA1B (0.52) | CACNA1BAAK1 | |
| SCHEMBL8257659 | 0.71 | CACNA1B (0.51) | CACNA1BAAK1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079743-B1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD (GB) | 2012-01-25 | — | — | EP | disclosed |
| WO-2008050096-A1 | PTERIDINE DERIVATIVES AS POLO-LIKE KINASE INHIBITORS USEFUL IN THE TREATMENT OF CANCER | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-02 | — | — | WO | disclosed |