Sugi Predict

Sugi Predict / Compounds / SCHEMBL10144710

SCHEMBL10144710

SCHEMBL10144710

CSc1ccc2c(c1)-c1cc([Si](c3ccccc3)(c3ccccc3)c3ccccc3)ccc1C2

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ CHRM1 P11229 2/20 0.37
▸ CHRM2 P08172 1/20 0.37
▸ CHRM4 P08173 1/20 0.37
▸ CHRM5 P08912 1/20 0.37
▸ CHRM3 P20309 1/20 0.37
▸ HTR7 P34969 1/20 0.35
▸ EIF2AK1 Q9BQI3 1/20 0.33
▸ TYMS P04818 1/20 0.33
▸ FGFR1 P11362 1/20 0.33
▸ SRD5A2 P31213 1/20 0.30
▸ KDM4E B2RXH2 1/20 0.30
▸ NPC1 O15118 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30
▸ LMNA P02545 1/20 0.30
▸ MAPT P10636 1/20 0.30
▸ HPGD P15428 1/20 0.30
▸ RAB9A P51151 1/20 0.30
▸ SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9920565 0.88 BCL2 (0.36) SRD5A2KDM4ENPC1ALDH1A1LMNA
SCHEMBL12219219 0.85 KDM4E (0.38) SRD5A2KDM4ENPC1ALDH1A1LMNA
SCHEMBL12879656 0.85 KDM4E (0.38) SRD5A2KDM4ENPC1ALDH1A1LMNA
SCHEMBL12879655 0.81 ESR1 (0.40) SRD5A2KDM4ENPC1ALDH1A1LMNA
SCHEMBL13138261 0.77 ALDH1A1 (0.43) KDM4EALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL10144709 0.76 ALDH1A1 (0.47) KDM4EALDH1A1MAPTHPGDSMN1; SMN2
SCHEMBL9920546 0.75 MAOA (0.35) SRD5A2KDM4ENPC1ALDH1A1LMNA
SCHEMBL30210980 0.75 ALDH1A1 (0.42) HTR7SRD5A2KDM4ENPC1ALDH1A1
SCHEMBL13138273 0.75 ALDH1A1 (0.42) HTR7SRD5A2KDM4ENPC1ALDH1A1
SCHEMBL12879658 0.75 ALDH1A1 (0.42) HTR7SRD5A2KDM4ENPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9458182-B2 Silyl- and heteroatom-substituted compounds selected from carbazoles, dibenzofurans, dibenzothiophenes and dibenzophospholes, and use thereof in organic electronics BASF SE (DE) 2016-10-04 — — US disclosed
US-8691401-B2 Bridged benzimidazole-carbene complexes and use thereof in OLEDS BASF SE (DE) 2014-04-08 — — US disclosed
US-20120012821-A1 SILYL- AND HETEROATOM-SUBSTITUTED COMPOUNDS SELECTED FROM CARBAZOLES, DIBENZOFURANS, DIBENZOTHIOPHENES AND DIBENZOPHOSPHOLES, AND USE THEREOF IN ORGANIC ELECTRONICS BASF SE (DE) 2012-01-19 — — US disclosed
US-20110253988-A1 BRIDGED BENZIMIDAZOLE-CARBENE COMPLEXES AND USE THEREOF IN OLEDS BASF SE (DE) 2011-10-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110253988-A1 BRIDGED BENZIMIDAZOLE-CARBENE COMPLEXES AND USE THEREOF IN OLEDS CCND1, DRD2, CCND2 CHRM1 11/4885CHRM2 13/4885CHRM4 25/4885
US-20120012821-A1 SILYL- AND HETEROATOM-SUBSTITUTED COMPOUNDS SELECTED FROM CARBAZOLES, DIBENZOFURANS, DIBENZOTHIOPHENES AND DIBENZOPHOSPHOLES, AND USE THEREOF IN ORGANIC ELECTRONICS DDT, CDKL1, CDK2 CHRM1 524/4885CHRM2 498/4885CHRM4 812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.