Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 3/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7867429 | 0.83 | CHRNA3 (0.36) | CHRNA3CHRNB2CHRNB4CHRNA7CHRNA4 | |
| SCHEMBL10145593 | 0.83 | CHRNB2 (0.39) | CHRNA3CHRNB2CHRNB4CHRNA7CHRNA4 | |
| SCHEMBL10145368 | 0.82 | CHRNA3 (0.44) | CHRNA3CHRNB2CHRNB4CHRNA7CHRNA4 | |
| SCHEMBL10121975 | 0.77 | CHRNB2 (0.38) | CHRNA3CHRNB2CHRNB4CHRNA7CHRNA4 | |
| SCHEMBL10145405 | 0.74 | CHRNA3 (0.54) | CHRNA3CHRNB2CHRNB4CHRNA7CHRNA4 | |
| SCHEMBL10144801 | 0.72 | CHRNA3 (0.37) | CHRNA3CHRNB2CHRNB4CHRNA7CHRNA4 | |
| SCHEMBL28033552 | 0.70 | SLC6A4 (0.47) | — | |
| Acetic Acid SCHEMBL27836187 | 0.69 | ACACB (0.44) | — | |
| SCHEMBL170306 | 0.66 | MAPT (0.42) | — | |
| SCHEMBL18700639 | 0.66 | L3MBTL1 (0.34) | CHRNA3CHRNB2CHRNB4CHRNA7CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120040991-A1 | 3-AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040991-A1 | 3-AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS | HCRTR2, HCRTR1, NPY2R | CHRNA3 77/4885CHRNB2 120/4885CHRNB4 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.