Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA3 | P32297 | 4/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10121975 | 0.84 | CHRNB2 (0.38) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL10144800 | 0.83 | CHRNA3 (0.44) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL28033552 | 0.68 | SLC6A4 (0.47) | SLC6A4 | |
| SCHEMBL170306 | 0.67 | MAPT (0.42) | SLC6A4 | |
| Acetic Acid SCHEMBL27836187 | 0.67 | ACACB (0.44) | — | |
| SCHEMBL10145593 | 0.66 | CHRNB2 (0.39) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL607998 | 0.65 | NPC1 (0.35) | CHRNB2CHRNA4SLC6A4 | |
| SCHEMBL619863 | 0.65 | CHRNB2 (0.38) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL10145368 | 0.64 | CHRNA3 (0.44) | CHRNA3CHRNB2CHRNA4CHRNB4CHRNA7 | |
| SCHEMBL14349236 | 0.63 | NUDT1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010122151-A1 | 3 -AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-10-28 | — | — | WO | disclosed |