Sugi Predict

Sugi Predict / Compounds / SCHEMBL10145555

SCHEMBL10145555

SCHEMBL10145555

CC(=O)Oc1ccc2c(c1)Oc1cc(N(C)c3ccc(N)cc3)ccc1C21OC(=O)c2ccccc21

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 5/20 0.76
▸ KMT2A Q03164 5/20 0.76
▸ MAPT P10636 5/20 0.76
▸ ALDH1A1 P00352 4/20 0.76
▸ HTT P42858 2/20 0.76
▸ LMNA P02545 2/20 0.76
▸ USP2 O75604 2/20 0.76
▸ GSTP1 P09211 1/20 0.57
▸ CYP3A4 P08684 2/20 0.53
▸ FTO Q9C0B1 5/20 0.48
▸ TDP1 Q9NUW8 3/20 0.48
▸ HPGD P15428 2/20 0.48
▸ RECQL P46063 2/20 0.48
▸ BLM P54132 2/20 0.48
▸ PRMT1 Q99873 2/20 0.48
▸ ACE2 Q9BYF1 2/20 0.48
▸ CYP2C19 P33261 1/20 0.48
▸ SMAD3 P84022 1/20 0.48
▸ POLB P06746 2/20 0.42
▸ ALOX12 P18054 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10145635 0.94 MAPT (0.82) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL15145535 0.91 MAPT (0.77) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL15145557 0.87 MAPT (0.70) MEN1KMT2AMAPTALDH1A1HTT
Fluorescein Diacetate SCHEMBL31658971 0.87 MAPT (1.00) MEN1KMT2AMAPTALDH1A1HTT
Fluorescein Diacetate SCHEMBL29353816 0.87 MAPT (1.00) MEN1KMT2AMAPTALDH1A1HTT
Fluorescein Diacetate SCHEMBL29453229 0.87 MAPT (1.00) MEN1KMT2AMAPTALDH1A1HTT
Fluorescein Diacetate SCHEMBL1028369 0.87 MAPT (1.00) MEN1KMT2AMAPTALDH1A1HTT
Fluorescein Diacetate SCHEMBL7648940 0.86 MAPT (0.98) MEN1KMT2AMAPTALDH1A1HTT
Fluorescein Diacetate SCHEMBL6248271 0.85 MAPT (0.95) MEN1KMT2AMAPTALDH1A1HTT
SCHEMBL10145408 0.84 FTO (0.70) MEN1KMT2AMAPTALDH1A1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2250177-B1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LTD (CN) 2014-06-18 — — EP disclosed
US-8114904-B2 Luminescence quenchers and fluorogenic probes for detection of reactive species Versitech Limited & Morningside Ventures Limited (CN) 2012-02-14 — — US disclosed
US-8114904-B2 Luminescence quenchers and fluorogenic probes for detection of reactive species Versitech Limited & Morningside Ventures Limited (CN) 2012-02-14 — — US disclosed
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — US disclosed
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — US disclosed
WO-2009121247-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES ROS1, LPO, HMOX1 MEN1 4478/4885KMT2A 3345/4885MAPT 4349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.