Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluorescein Diacetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.95 |
| ▸ | MEN1 | O00255 | 4/20 | 0.95 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.95 |
| ▸ | LMNA | P02545 | 4/20 | 0.95 |
| ▸ | HTT | P42858 | 2/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.95 |
| ▸ | USP2 | O75604 | 2/20 | 0.95 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | FTO | Q9C0B1 | 5/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.60 |
| ▸ | RECQL | P46063 | 2/20 | 0.60 |
| ▸ | BLM | P54132 | 2/20 | 0.60 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.60 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorescein Diacetate SCHEMBL1028369 | 0.98 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHTT | |
| Fluorescein Diacetate SCHEMBL29453229 | 0.98 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHTT | |
| Fluorescein Diacetate SCHEMBL31658971 | 0.98 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHTT | |
| Fluorescein Diacetate SCHEMBL29353816 | 0.98 | MAPT (1.00) | MAPTMEN1KMT2ALMNAHTT | |
| Fluorescein Diacetate SCHEMBL7648940 | 0.96 | MAPT (0.98) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL21075909 | 0.93 | MAPT (0.91) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL14769054 | 0.92 | MAPT (0.89) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL2285435 | 0.92 | MAPT (0.89) | MAPTMEN1KMT2ALMNAHTT | |
| Fluorescein Diacetate SCHEMBL1702382 | 0.91 | MAPT (0.87) | MAPTMEN1KMT2ALMNAHTT | |
| Fluorescein Diacetate SCHEMBL1701744 | 0.91 | MAPT (0.87) | MAPTMEN1KMT2ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948639-B1 | IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION | COULTER INT CORP (US) | 2005-08-10 | — | — | EP | disclosed |
| EP-0948639-A4 | IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION | COULTER INT CORP (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0948639-A1 | IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION | Coulter International Corp. (US) | 1999-10-13 | — | — | EP | disclosed |
| US-5905031-A | Identification of blast cells in a leukocyte cell preparation | COULTER INTERNATIONAL CORP. (US) | 1999-05-18 | — | — | US | disclosed |
| WO-1998020154-A1 | IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION | COULTER INTERNATIONAL CORP. (US) | 1998-05-14 | — | — | WO | disclosed |