Sugi Predict

Sugi Predict / Compounds / SCHEMBL10145570

SCHEMBL10145570

SCHEMBL10145570

O=C(O)c1ccccc1-c1c2ccc3cc(Nc4ccc(O)cc4)ccc3c2oc2c1ccc1cc(=O)ccc12

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SOS1 Q07889 2/20 0.78
▸ GNG2 P59768 2/20 0.43
▸ GNB1 P62873 2/20 0.43
▸ PRMT1 Q99873 2/20 0.42
▸ DNASE1L3 Q13609 1/20 0.42
▸ CYP2C9 P11712 2/20 0.41
▸ HCAR2 Q8TDS4 2/20 0.41
▸ PTPN7 P35236 1/20 0.39
▸ ALDH1A1 P00352 2/20 0.37
▸ HPGD P15428 2/20 0.37
▸ KDM4E B2RXH2 1/20 0.37
▸ USP2 O75604 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ CYP2C8 P10632 1/20 0.37
▸ MEN1 O00255 1/20 0.36
▸ THRB P10828 1/20 0.36
▸ HTT P42858 1/20 0.36
▸ RECQL P46063 1/20 0.36
▸ BLM P54132 1/20 0.36
▸ KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13648663 0.91 SOS1 (0.67) SOS1GNG2GNB1PRMT1DNASE1L3
SCHEMBL10059473 0.88 SOS1 (1.00) SOS1GNG2GNB1PRMT1DNASE1L3
SCHEMBL2737206 0.83 SOS1 (0.85) SOS1GNG2GNB1PRMT1DNASE1L3
SCHEMBL13648665 0.82 SOS1 (0.76) SOS1GNG2GNB1PRMT1CYP2C9
SCHEMBL15217880 0.80 SOS1 (0.76) SOS1GNG2GNB1CYP2C9HCAR2
SCHEMBL7602054 0.78 SOS1 (0.80) SOS1GNG2GNB1PRMT1DNASE1L3
SCHEMBL10145463 0.78 SOS1 (0.72) SOS1GNG2GNB1PRMT1CYP2C9
SCHEMBL10175951 0.78 SOS1 (0.72) SOS1GNG2GNB1CYP2C9HCAR2
SCHEMBL29543257 0.75 SOS1 (0.76) SOS1PRMT1DNASE1L3CYP2C9HCAR2
SCHEMBL17312264 0.75 SOS1 (0.76) SOS1PRMT1DNASE1L3CYP2C9HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2250177-B1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LTD (CN) 2014-06-18 — — EP disclosed
US-8114904-B2 Luminescence quenchers and fluorogenic probes for detection of reactive species Versitech Limited & Morningside Ventures Limited (CN) 2012-02-14 — — US disclosed
US-8114904-B2 Luminescence quenchers and fluorogenic probes for detection of reactive species Versitech Limited & Morningside Ventures Limited (CN) 2012-02-14 — — US disclosed
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — US disclosed
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — US disclosed
WO-2009121247-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES VERSITECH LIMITED (CN) 2009-10-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253118-A1 LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES ROS1, LPO, HMOX1 SOS1 1103/4885GNG2 1090/4885GNB1 1110/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.