Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14993287 | 0.84 | PRMT5 (0.38) | GRM2MEN1KMT2AHTTNPC1 | |
| SCHEMBL10145910 | 0.81 | GRM2 (0.60) | GRM2PARG | |
| SCHEMBL10145993 | 0.72 | GRM2 (0.60) | GRM2PARG | |
| SCHEMBL10145981 | 0.72 | CYP11B1 (0.39) | GRM2KMT2AGRIN1GRIN2BMAPK14 | |
| SCHEMBL10145864 | 0.71 | GRM2 (0.59) | GRM2PARG | |
| SCHEMBL10146004 | 0.71 | BRD4 (0.48) | GRM2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL10146361 | 0.71 | GRM2 (0.62) | GRM2ALDH1A1PARG | |
| SCHEMBL10145941 | 0.69 | GRM2 (0.47) | GRM2MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL10145948 | 0.69 | GRM2 (0.49) | GRM2L3MBTL1MAPK14 | |
| SCHEMBL10145952 | 0.68 | GRM2 (0.45) | GRM2NPC1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |