Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | PARG | Q86W56 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPD | P32754 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14992138 | 0.83 | PPARG (0.47) | BRD4PARGMEN1KMT2AGRM2 | |
| SCHEMBL10145948 | 0.82 | GRM2 (0.49) | GRM2HPD | |
| SCHEMBL10146668 | 0.80 | GRM2 (0.70) | PARGGRM2 | |
| SCHEMBL10145941 | 0.80 | GRM2 (0.47) | MEN1KMT2AGRM2ALDH1A1NPC1 | |
| SCHEMBL10146676 | 0.80 | GRM2 (0.47) | BRD4PARGGRM2ALDH1A1HPD | |
| SCHEMBL10145950 | 0.79 | MAPK14 (0.53) | BRD4GRM2ALDH1A1KDM4EMAPT | |
| SCHEMBL10145952 | 0.78 | GRM2 (0.45) | GRM2HDAC1NPC1KDM4EMAPT | |
| SCHEMBL10146671 | 0.77 | PARG (0.51) | PARGGRM2 | |
| SCHEMBL10145910 | 0.73 | GRM2 (0.60) | PARGGRM2 | |
| SCHEMBL10145993 | 0.73 | GRM2 (0.60) | PARGGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |