Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 2/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | HPD | P32754 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10145941 | 0.92 | GRM2 (0.47) | GRM2METAP2MAPK14CHEK1HPD | |
| SCHEMBL10145952 | 0.90 | GRM2 (0.45) | GRM2METAP2MAPK14 | |
| SCHEMBL10146668 | 0.85 | GRM2 (0.70) | GRM2METAP2 | |
| SCHEMBL10146676 | 0.85 | GRM2 (0.47) | GRM2METAP2MAPK14CHEK1HPD | |
| SCHEMBL10145950 | 0.84 | MAPK14 (0.53) | GRM2METAP2MAPK14CHEK1 | |
| SCHEMBL10146671 | 0.82 | PARG (0.51) | GRM2METAP2MAPK14CHEK1 | |
| SCHEMBL10146004 | 0.82 | BRD4 (0.48) | GRM2HPD | |
| SCHEMBL627348 | 0.81 | GRM2 (0.46) | GRM2MAPK14ADORA2BADORA2AADORA1 | |
| SCHEMBL10146672 | 0.77 | PARG (0.46) | GRM2METAP2MAPK14ADORA2ACHEK1 | |
| SCHEMBL24665898 | 0.75 | CYP1A2 (0.61) | POLBTHRBL3MBTL1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |