Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | PIK3R2 | O00459 | 14/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1694949 | 0.91 | PIK3R2 (0.39) | PIK3R2EGFRERBB2PIK3CDPIK3CG | |
| SCHEMBL10147624 | 0.87 | PIK3R2 (0.42) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL10147627 | 0.85 | PTGES (0.39) | AURKARPS6KB1PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1695309 | 0.83 | MAPK8 (0.43) | AURKARPS6KB1PIK3R2EGFRERBB2 | |
| SCHEMBL1695242 | 0.83 | PIK3R2 (0.39) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695135 | 0.82 | PIK3R2 (0.43) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695343 | 0.81 | PIK3R2 (0.41) | PIK3R2EGFRPIK3CDPIK3CGPIK3CA | |
| SCHEMBL1695420 | 0.81 | PIK3R2 (0.41) | PIK3R2PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL1695362 | 0.81 | PIK3R2 (0.41) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL1694753 | 0.80 | PIK3R2 (0.39) | AURKARPS6KB1PIK3R2PIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003274-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |