SCHEMBL101479

SCHEMBL101479

FC(F)(F)c1[c]ccc(Cl)c1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.31
AHR P35869 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5198912 0.79 ALOX5 (0.41) PDK2
SCHEMBL11054093 0.79 TSHR (0.43)
SCHEMBL15286936 0.78 ALOX5 (0.38) PDK2AHR
SCHEMBL206642 0.77
SCHEMBL15637460 0.77 AHR (0.44) PDK2AHR
SCHEMBL17144533 0.75
SCHEMBL900969 0.75
SCHEMBL149760 0.74 TSHR (0.37)
SCHEMBL262756 0.74 NT5E (0.30)
SCHEMBL21630312 0.74 AR (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1055 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117618423-A Inhibitors of tryptophan dioxygenase (IDO 1 and TDO) and their use in therapy 奥克兰联合服务有限公司 2024-03-01 CN claimed
CN-117599049-A Inhibitors of tryptophan dioxygenase (IDO 1 and TDO) and their use in therapy 奥克兰联合服务有限公司 2024-02-27 CN claimed
WO-2023239709-A2 TARGETING AN ENZYME REQUIRED FOR ACUTE MYELOID LEUKEMIA ALBERT EINSTEIN COLLEGE OF MEDICINE (US) 2023-12-14 WO claimed
US-20230339904-A1 ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS BIOTHERYX, INC. 2023-10-26 US claimed
CN-116693430-A 2-amido tertiary butyl sulfonamide compound, and preparation method and application thereof 沈阳农业大学 2023-09-05 CN claimed
CN-115073370-A Novel alkylammonium compound or salt, isomer, preparation method and application thereof 成都硕德药业有限公司 2022-09-20 CN claimed
CN-112341404-A Novel thiazole derivative or salt, isomer, preparation method and application thereof 成都苑东生物制药股份有限公司 2021-02-09 CN claimed
CN-108530455-B Urea substituted aromatic ring connecting dioxane and quinazoline compound or medicinal salt or hydrate and application as tyrosine kinase inhibitor 北京赛特明强医药科技有限公司 2021-01-12 CN claimed
EP-3728235-A1 SUBSTITUTED THIOPHENYL URACILS, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS Syngenta Crop Protection AG (CH) 2020-10-28 EP claimed
US-10781180-B2 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto ARENA PHARMACEUTICALS, INC. (US) 2020-09-22 US claimed
EP-0264988-A1 Fungicidal compositions SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1988-04-27 EP claimed
EP-0253447-A1 Imidazole derivatives, their preparation and their use as fungicides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1988-01-20 EP claimed
US-4678504-A O-substituted 3-oxypridinium salts, their preparation and their use as fungicides for crop protection BASF AKTIENGESELLSCHAFT (DE) 1987-07-07 US claimed
EP-0207411-A1 0-substituted 3-oxy-pyridinium salts, process for their preparation and their use as fungicides in crop protection BASF Aktiengesellschaft (DE) 1987-01-07 EP claimed
EP-0191514-A1 Imidazole derivatives, their preparation and their use as fungicides SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1986-08-20 EP claimed
US-4512989-A IMIDOESTERS OR IMIDOTHIOESTERS HOKKO CHEMICAL INDUSTRY CO., LTD. (JP) 1985-04-23 US claimed
EP-0130366-A2 Arylalkylimidazolium and triazolium salts, process for their preparation and their use as microbicides BASF Aktiengesellschaft (DE) 1985-01-09 EP claimed
US-4364955-A PLANT FUNGI BAYER AKTIENGESELLSCHAFT (DE) 1982-12-21 US claimed
US-4197403-A ANTIINFLAMMATORY, IMMUNOSUPPRESSIVE, FUNGICIDE WESTWOOD PHARMACEUTICALS INC. (US) 1980-04-08 US claimed
US-4085099-A AZO DYES PRODUITS CHIMIQUES UGINE KUHLMANN (FR) 1978-04-18 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230339904-A1 ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS CSNK1A1, CSNK1D, CSNK1G1 PDK2 436/4885AHR 4371/4885
US-10781180-B2 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto HTR5A, HTR3A, HTR2A PDK2 2950/4885AHR 295/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.