Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | TTR | P02766 | 3/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 4/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12420683 | 0.96 | XDH (0.50) | MAP4K4TTRRBP4PARP10PARP15 | |
| SCHEMBL662159 | 0.94 | TTR (0.50) | MAP4K4TTRRBP4PARP10PARP15 | |
| SCHEMBL10148081 | 0.89 | MAP4K4 (0.54) | MAP4K4TTRRBP4PARP10PARP15 | |
| SCHEMBL24968525 | 0.87 | KDM4C (0.53) | MAP4K4TTRRBP4PDE4BPDE4A | |
| SCHEMBL15968784 | 0.82 | LMNA (0.55) | MAP4K4TTRRBP4PARP10PARP15 | |
| SCHEMBL6940040 | 0.82 | TSHR (0.62) | MAP4K4TTRXDHPDE4BPDE4A | |
| SCHEMBL7374749 | 0.81 | PDE4B (0.69) | MAP4K4PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL13806376 | 0.81 | PARP10 (0.46) | PARP10PARP15PARP2XDHPDE4B | |
| SCHEMBL18374473 | 0.81 | PDE4B (0.49) | PARP10PARP15PARP2PDE4BPDE4A | |
| SCHEMBL28034346 | 0.80 | PDE4B (0.53) | MAP4K4PARP10PARP15PARP2XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2012-02-23 | — | — | US | disclosed |
| WO-2010122968-A1 | DIACYLETHYLENEDIAMINE COMPOUND | アステラス製薬株式会社 (JP) | 2010-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046292-A1 | DIACYLETHYLENEDIAMINE COMPOUND | DGAT1, DGAT2, DIMT1 | MAP4K4 3718/4885TTR 4836/4885RBP4 3074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.