Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ACR | P10323 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27810220 | 0.79 | ALDH1A1 (0.56) | MAPTALDH1A1NPC1SMN1; SMN2HPGD | |
| SCHEMBL11639996 | 0.78 | NPC1 (0.58) | MAPTALDH1A1NPC1SMN1; SMN2HPGD | |
| SCHEMBL1012633 | 0.75 | ALDH1A1 (0.51) | MAPTCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL15190381 | 0.74 | FAAH (0.55) | MAPTGAAPOLBALDH1A1NPC1 | |
| SCHEMBL15190342 | 0.74 | FAAH (0.55) | MAPTPOLBALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL15189997 | 0.73 | FAAH (0.54) | MAPTGAAPOLBALDH1A1NPC1 | |
| SCHEMBL15190439 | 0.73 | RAB9A (0.57) | MAPTPOLBALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL11173405 | 0.73 | ALDH1A1 (0.51) | MAPTCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL11250840 | 0.73 | ALDH1A1 (0.47) | MAPTGAAALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL8846987 | 0.72 | ALDH1A1 (0.54) | MAPTALDH1A1NPC1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268623-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117080-A1 | QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATON (US) | 2009-09-24 | — | — | WO | disclosed |