Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153984 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4EMAPTMEN1KMT2A | |
| SCHEMBL10153683 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EMAPTRAB9ANPC1 | |
| SCHEMBL9961071 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2KDM4EMAPTMEN1KMT2A | |
| SCHEMBL28438951 | 0.82 | RAB9A (0.68) | SMN1; SMN2KDM4EMAPTMEN1KMT2A | |
| SCHEMBL10153648 | 0.81 | ALDH1A1 (0.59) | SMN1; SMN2KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6859800 | 0.80 | MAPT (0.64) | SMN1; SMN2KDM4EMAPTMEN1KMT2A | |
| SCHEMBL20522767 | 0.79 | RAB9A (0.66) | SMN1; SMN2KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7050973 | 0.79 | KCNK9 (0.67) | SMN1; SMN2KDM4EMAPTMEN1KMT2A | |
| SCHEMBL4241238 | 0.76 | KMT2A (0.68) | SMN1; SMN2KDM4EMAPTMEN1KMT2A | |
| SCHEMBL11170486 | 0.76 | RAB9A (0.62) | SMN1; SMN2KDM4EMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012085003-A1 | 2-HYDROXYISOQUINOLINE-1,3(2H,4H)-DIONES AND RELATED COMPOUNDS USEFUL AS HIV REPLICATION INHIBITORS | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-06-28 | — | — | WO | disclosed |