Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 6/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21388683 | 0.87 | NPC1 (0.48) | NPC1RECQLRAB9ASMN1; SMN2CTSK | |
| SCHEMBL13920479 | 0.87 | MIF (0.48) | CTSKCTSSMAPTATM | |
| SCHEMBL14847516 | 0.85 | TRPA1 (0.45) | CTSKCTSSALDH1A1MAPTCACNA1B | |
| SCHEMBL15952332 | 0.85 | TRPA1 (0.45) | CTSKCTSSALDH1A1MAPTCACNA1B | |
| SCHEMBL4715202 | 0.85 | CTSK (0.52) | CTSKCTSSMAPTATM | |
| SCHEMBL10896010 | 0.85 | CTSK (0.52) | CTSKCTSSMAPTATM | |
| SCHEMBL19348989 | 0.85 | CTSK (0.52) | CTSKCTSSMAPTATM | |
| SCHEMBL30109141 | 0.84 | MAPT (0.50) | CTSKCTSSMAPTATM | |
| SCHEMBL14023116 | 0.84 | NPSR1 (0.49) | RAB9ACTSKCTSSALDH1A1MAPT | |
| SCHEMBL31269578 | 0.83 | ALDH1A1 (0.44) | CTSKALDH1A1MAPTCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009226-A1 | SUBSTITUTED IMIDAZOLONES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |