Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.42 |
| ▸ | STK4 | Q13043 | 1/20 | 0.42 |
| ▸ | STK3 | Q13188 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL424750 | 0.96 | PRKDC (0.43) | MTORPIK3CASIGMAR1MAPK9MAPKAPK2 | |
| SCHEMBL424865 | 0.88 | MTOR (0.43) | MTORPIK3CASTK4STK3LRRK2 | |
| SCHEMBL426084 | 0.88 | MTOR (0.43) | MTORPIK3CAACHEALDH1A1POLB | |
| SCHEMBL426124 | 0.88 | ALDH1A1 (0.48) | MTORPIK3CASIGMAR1ACHEKDM4E | |
| SCHEMBL428680 | 0.84 | PIK3CA (0.47) | MTORPIK3CASIGMAR1STK4STK3 | |
| SCHEMBL430672 | 0.83 | PIK3CA (0.44) | MTORPIK3CASIGMAR1STK4STK3 | |
| SCHEMBL425603 | 0.82 | NOS1 (0.50) | MTORPIK3CASIGMAR1STK4STK3 | |
| SCHEMBL422993 | 0.79 | ACHE (0.49) | PIK3CAACHEKDM4EMEN1ALDH1A1 | |
| SCHEMBL427063 | 0.78 | LMNA (0.49) | MTORPIK3CASTK4STK3LRRK2 | |
| SCHEMBL423981 | 0.78 | MKNK1 (0.42) | MTORPIK3CASIGMAR1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021434-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-01-26 | — | — | US | disclosed |
| US-20120021434-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-01-26 | — | — | US | disclosed |