Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | DPP4 | P27487 | 6/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | TLR4 | O00206 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843520 | 0.88 | ALDH1A1 (0.58) | ALDH1A1GAATSHREPHX1MEN1 | |
| SCHEMBL9029185 | 0.88 | ALDH1A1 (0.58) | ALDH1A1GAATSHREPHX1MEN1 | |
| SCHEMBL3948461 | 0.87 | ALDH1A1 (0.85) | ALDH1A1GAATSHREPHX1MEN1 | |
| SCHEMBL381922 | 0.87 | ALDH1A1 (0.85) | ALDH1A1GAATSHREPHX1MEN1 | |
| SCHEMBL3948456 | 0.87 | ALDH1A1 (0.85) | ALDH1A1GAATSHREPHX1MEN1 | |
| SCHEMBL5029247 | 0.87 | ALDH1A1 (0.64) | ALDH1A1GAATSHREPHX1MEN1 | |
| SCHEMBL17872903 | 0.86 | ALDH1A1 (0.71) | ALDH1A1GAATSHREPHX1MEN1 | |
| SCHEMBL15328920 | 0.86 | ALDH1A1 (0.71) | ALDH1A1GAATSHREPHX1MEN1 | |
| SCHEMBL3365910 | 0.86 | ALDH1A1 (0.71) | ALDH1A1GAATSHREPHX1MEN1 | |
| SCHEMBL5029401 | 0.86 | ALDH1A1 (0.63) | ALDH1A1GAATSHREPHX1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200155689-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. | 2020-05-21 | — | — | US | disclosed |
| US-8470828-B2 | Anellated pyridine compounds | HOFFMANN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120010201-A1 | NOVEL ANELLATED PYRIDINE COMPOUNDS | HOFFMANN-LA ROCHE INC. | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155689-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | ALDH1A1 3671/4885GAA 1175/4885TSHR 3772/4885 |
| US-20120010201-A1 | NOVEL ANELLATED PYRIDINE COMPOUNDS | ADORA3, ADORA2A, HTR3A | ALDH1A1 450/4885GAA 4051/4885TSHR 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.